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ZNF264 zinc finger protein 264 [ Homo sapiens (human) ]

Gene ID: 9422, updated on 10-Oct-2019

Summary

Official Symbol
ZNF264provided by HGNC
Official Full Name
zinc finger protein 264provided by HGNC
Primary source
HGNC:HGNC:13057
See related
Ensembl:ENSG00000083844 MIM:604668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF264 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57191500..57222846)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57702868..57734214)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene double homeobox A Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-05-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-05-10)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Wnt signaling and Dupuytren's disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016432.1 RefSeqGene

    Range
    5001..36347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003417.5NP_003408.1  zinc finger protein 264

    See identical proteins and their annotated locations for NP_003408.1

    Status: REVIEWED

    Source sequence(s)
    AB007872, AC005261, AK292504, BF063192
    Consensus CDS
    CCDS33127.1
    UniProtKB/Swiss-Prot
    O43296
    Related
    ENSP00000263095.5, ENST00000263095.10
    Conserved Domains (6) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:184568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399421
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57191500..57222846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527522.2XP_011525824.1  zinc finger protein 264 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:1456
    KRAB; krueppel associated box
    COG5048
    Location:152536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:453473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:367389
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:381406
    zf-H2C2_2; Zinc-finger double domain
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