U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lrp1b low density lipoprotein-related protein 1B [ Mus musculus (house mouse) ]

Gene ID: 94217, updated on 24-Sep-2025
Official Symbol
Lrp1bprovided by MGI
Official Full Name
low density lipoprotein-related protein 1Bprovided by MGI
Primary source
MGI:MGI:2151136
See related
Ensembl:ENSMUSG00000049252 AllianceGenome:MGI:2151136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LRP-DIT; 9630004P12Rik
Summary
Enables low-density lipoprotein particle receptor activity. Acts upstream of or within in utero embryonic development. Located in membrane. Is expressed in several structures, including adrenal medulla; central nervous system; and eye. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in frontal lobe adult (RPKM 1.7), cortex adult (RPKM 1.4) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table
See Lrp1b in Genome Data Viewer
Location:
2 B; 2 24.51 cM
Exon count:
93
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (40485302..42543747, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (40595290..42653598, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04359 Neighboring gene STARR-seq mESC enhancer starr_04361 Neighboring gene predicted gene, 24467 Neighboring gene STARR-seq mESC enhancer starr_04362 Neighboring gene STARR-seq mESC enhancer starr_04363 Neighboring gene STARR-seq mESC enhancer starr_04364 Neighboring gene STARR-positive B cell enhancer mm9_chr2:40476998-40477299 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04365 Neighboring gene STARR-seq mESC enhancer starr_04366 Neighboring gene STARR-seq mESC enhancer starr_04367 Neighboring gene STARR-seq mESC enhancer starr_04368 Neighboring gene ash2 (absent, small, or homeotic)-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_04370 Neighboring gene STARR-seq mESC enhancer starr_04372 Neighboring gene predicted gene, 30138 Neighboring gene STARR-seq mESC enhancer starr_04373 Neighboring gene STARR-seq mESC enhancer starr_04374 Neighboring gene STARR-seq mESC enhancer starr_04375 Neighboring gene STARR-seq mESC enhancer starr_04376 Neighboring gene STARR-seq mESC enhancer starr_04377 Neighboring gene RAN, member RAS oncogene family, pseudogene Neighboring gene microRNA 6336 Neighboring gene STARR-seq mESC enhancer starr_04378 Neighboring gene STARR-seq mESC enhancer starr_04379 Neighboring gene STARR-seq mESC enhancer starr_04380 Neighboring gene STARR-seq mESC enhancer starr_04381 Neighboring gene predicted gene, 24350 Neighboring gene predicted gene, 39803

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation. Knisely JM, et al. Exp Cell Res, 2007 Sep 10. PMID 17658514, Free PMC Article
  2. Mutagenic insertion and chromosome engineering resource (MICER). Adams DJ, et al. Nat Genet, 2004 Aug. PMID 15235602
  3. Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member. Beer AG, et al. Oncotarget, 2016 Oct 18. PMID 27626682, Free PMC Article
  4. Striking differences of LDL receptor-related protein 1B expression in mouse and human. Li Y, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15963947
  5. Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1. Shiroshima T, et al. FEBS Lett, 2009 Jan 5. PMID 19071120

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that overexpression of full-length mouse Lrp1b leads to impaired cellular proliferation, while human LRP1B knockdown has the opposite effect.
    Title: Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member.
  2. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
    Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
  3. the extracellular domains may function as a scavenger for signaling ligands or signal modulators in the extracellular space, thereby preserving signaling thresholds that are critical for embryonic development
    Title: Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.
  4. This study presents the possibility that LRP1B participates in signal transduction which PICK1 may regulate by inhibiting PKCalpha phosphorylation of LRP1B.
    Title: Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
  5. both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate.
    Title: Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.
  6. Results show that in contrast to LRP1, LRP1b-deficient mice develop normally, most likely due to its restricted expression pattern and functional compensation by LRP1 or other receptors.
    Title: Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cargo receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
Preferred Names
low-density lipoprotein receptor-related protein 1B
Names
LRP-1B
low density lipoprotein-related protein 1B (deleted in tumors)
low-density lipoprotein receptor-related protein-deleted in tumor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053011.2 → NP_443737.2  low-density lipoprotein receptor-related protein 1B precursor

    Status: VALIDATED

    Source sequence(s)
    AL805948, AL840626, AL844225, AL844515, AL844533, AL844553, AL845293, AL928732, AL928962, AL928981, BX000439, BX649304
    Consensus CDS
    CCDS84520.1
    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    UniProtKB/TrEMBL
    A2API5
    Related
    ENSMUSP00000054275.8, ENSMUST00000052550.13
    Conserved Domains (11) summary
    smart00192
    Location:926 → 958
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1947 → 1987
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2968 → 3002
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4250 → 4284
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3476 → 3510
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1913 → 1952
    NHL; NHL repeat [structural motif]
    pfam00057
    Location:1100 → 1131
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:2330 → 2371
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:2948 → 2971
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3277 → 3313
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:1913 → 2138
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    40485302..42543747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498463.5 → XP_006498526.1  low-density lipoprotein receptor-related protein 1B isoform X5

    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    Conserved Domains (12) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2918 → 2952
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4200 → 4234
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3426 → 3460
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1131 → 1162
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam12662
    Location:2898 → 2921
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3227 → 3263
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:3989 → 4029
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  2. XM_017319348.3 → XP_017174837.1  low-density lipoprotein receptor-related protein 1B isoform X3

    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    Conserved Domains (12) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2999 → 3033
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4238 → 4272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3507 → 3541
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1131 → 1162
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam12662
    Location:2979 → 3002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3308 → 3344
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:4027 → 4067
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  3. XM_006498462.5 → XP_006498525.1  low-density lipoprotein receptor-related protein 1B isoform X4

    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    Conserved Domains (12) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2999 → 3033
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4281 → 4315
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3507 → 3541
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1131 → 1162
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam12662
    Location:2979 → 3002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3308 → 3344
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:4070 → 4110
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  4. XM_006498460.5 → XP_006498523.1  low-density lipoprotein receptor-related protein 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    Conserved Domains (12) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2999 → 3033
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4281 → 4315
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3507 → 3541
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1131 → 1162
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam12662
    Location:2979 → 3002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3308 → 3344
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:4070 → 4110
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  5. XM_006498459.5 → XP_006498522.1  low-density lipoprotein receptor-related protein 1B isoform X1

    UniProtKB/Swiss-Prot
    Q8BZD3, Q8BZM7, Q9JI18
    Conserved Domains (12) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2999 → 3033
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4281 → 4315
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3507 → 3541
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1131 → 1162
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam12662
    Location:2979 → 3002
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3308 → 3344
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:4070 → 4110
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  6. XM_011239217.4 → XP_011237519.1  low-density lipoprotein receptor-related protein 1B isoform X6

    Conserved Domains (8) summary
    smart00192
    Location:957 → 989
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1978 → 2018
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1084 → 1119
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:1944 → 1983
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:2361 → 2402
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:1944 → 2169
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:997 → 1033
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:1207 → 1243
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. XR_374143.5 RNA Sequence

  2. XR_374144.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI18.1 GenPept UniProtKB/Swiss-Prot:Q9JI18

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools