Lrp1b low density lipoprotein-related protein 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrp1bprovided by MGI
Official Full Name: low density lipoprotein-related protein 1Bprovided by MGI
Primary source: MGI:MGI:2151136
See related: Ensembl:ENSMUSG00000049252 AllianceGenome:MGI:2151136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LRP-DIT; 9630004P12Rik
Summary: Enables low-density lipoprotein particle receptor activity. Acts upstream of or within in utero embryonic development. Located in membrane. Is expressed in several structures, including central nervous system and eye. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 1.7), cortex adult (RPKM 1.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 B

Exon count:: 93

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (40485302..42543747, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (40595290..42653598, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that overexpression of full-length mouse Lrp1b leads to impaired cellular proliferation, while human LRP1B knockdown has the opposite effect.
Title: Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member.
C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
the extracellular domains may function as a scavenger for signaling ligands or signal modulators in the extracellular space, thereby preserving signaling thresholds that are critical for embryonic development
Title: Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.
This study presents the possibility that LRP1B participates in signal transduction which PICK1 may regulate by inhibiting PKCalpha phosphorylation of LRP1B.
Title: Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
both halves of the LRP1B cytoplasmic tail contribute to a unique global conformation, which results in less efficient recognition by endocytic adaptors and a slow endocytosis rate.
Title: Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.
Results show that in contrast to LRP1, LRP1b-deficient mice develop normally, most likely due to its restricted expression pattern and functional compensation by LRP1 or other receptors.
Title: Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Ucl4 (e-PCR), detects polymorphism
- UniSTS:142359

D2Mit297 (e-PCR), detects polymorphism
- UniSTS:116269

D9Mco7 (e-PCR)
- UniSTS:239669

D2Mit237 (e-PCR), detects polymorphism
- UniSTS:129114

D2Mit466 (e-PCR), detects polymorphism
- UniSTS:129377

D2Mit468 (e-PCR), detects polymorphism
- UniSTS:129379

Lrp1b (e-PCR), detects polymorphism
- UniSTS:471190

D2Dcr49 (e-PCR), detects polymorphism
- UniSTS:507608

BB284142 (e-PCR)
- UniSTS:207327

24.MHAa81T_M13Rev.seq (e-PCR)
- UniSTS:123626

D2Mit369 (e-PCR), detects polymorphism
- UniSTS:129265

D2Mit370 (e-PCR), detects polymorphism
- UniSTS:129267

D2Mit371 (e-PCR), detects polymorphism
- UniSTS:129268

NoName (e-PCR)
- UniSTS:224757

Homology

Orthologs from Annotation Pipeline: 451 organisms have orthologs with human gene Lrp1b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables low-density lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 1B

Names: LRP-1B; low density lipoprotein-related protein 1B (deleted in tumors); low-density lipoprotein receptor-related protein-deleted in tumor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053011.2 → NP_443737.2 low-density lipoprotein receptor-related protein 1B precursor

Status: VALIDATED

Source sequence(s)

AL805948, AL840626, AL844225, AL844515, AL844533, AL844553, AL845293, AL928732, AL928962, AL928981, BX000439, BX649304

Consensus CDS

CCDS84520.1

UniProtKB/TrEMBL

A2API5

Related

ENSMUSP00000054275.8, ENSMUST00000052550.13

Conserved Domains (11) summary

smart00192
Location:926 → 958

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1947 → 1987

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2968 → 3002

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4250 → 4284

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3476 → 3510

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1913 → 1952

NHL; NHL repeat [structural motif]

pfam00057
Location:1100 → 1131

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:2330 → 2371

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam12662
Location:2948 → 2971

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3277 → 3313

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl18310
Location:1913 → 2138

NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

40485302..42543747 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498463.5 → XP_006498526.1 low-density lipoprotein receptor-related protein 1B isoform X5

Conserved Domains (12) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2918 → 2952

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4200 → 4234

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3426 → 3460

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:1131 → 1162

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam12662
Location:2898 → 2921

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3227 → 3263

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl39070
Location:3989 → 4029

Ldl_recept_b; Low-density lipoprotein receptor repeat class B
XM_017319348.3 → XP_017174837.1 low-density lipoprotein receptor-related protein 1B isoform X3

Conserved Domains (12) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2999 → 3033

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4238 → 4272

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3507 → 3541

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:1131 → 1162

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam12662
Location:2979 → 3002

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3308 → 3344

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl39070
Location:4027 → 4067

Ldl_recept_b; Low-density lipoprotein receptor repeat class B
XM_006498462.5 → XP_006498525.1 low-density lipoprotein receptor-related protein 1B isoform X4

Conserved Domains (12) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2999 → 3033

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4281 → 4315

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3507 → 3541

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:1131 → 1162

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam12662
Location:2979 → 3002

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3308 → 3344

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl39070
Location:4070 → 4110

Ldl_recept_b; Low-density lipoprotein receptor repeat class B
XM_006498460.5 → XP_006498523.1 low-density lipoprotein receptor-related protein 1B isoform X2

Conserved Domains (12) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2999 → 3033

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4281 → 4315

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3507 → 3541

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:1131 → 1162

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam12662
Location:2979 → 3002

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3308 → 3344

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl39070
Location:4070 → 4110

Ldl_recept_b; Low-density lipoprotein receptor repeat class B
XM_006498459.5 → XP_006498522.1 low-density lipoprotein receptor-related protein 1B isoform X1

Conserved Domains (12) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2999 → 3033

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4281 → 4315

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00112
Location:3507 → 3541

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:1131 → 1162

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam12662
Location:2979 → 3002

cEGF; Complement Clr-like EGF-like

pfam14670
Location:3308 → 3344

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl39070
Location:4070 → 4110

Ldl_recept_b; Low-density lipoprotein receptor repeat class B
XM_011239217.4 → XP_011237519.1 low-density lipoprotein receptor-related protein 1B isoform X6

Conserved Domains (8) summary

smart00192
Location:957 → 989

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:1978 → 2018

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1084 → 1119

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:1944 → 1983

NHL; NHL repeat [structural motif]

pfam00058
Location:2361 → 2402

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl18310
Location:1944 → 2169

NHL; NHL repeat unit of beta-propeller proteins

pfam00057
Location:997 → 1033

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:1207 → 1243

FXa_inhibition; Coagulation Factor Xa inhibitory site