Format

Send to:

Choose Destination

Ece1 endothelin converting enzyme 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94204, updated on 30-Sep-2021

Summary

Official Symbol
Ece1provided by RGD
Official Full Name
endothelin converting enzyme 1provided by RGD
Primary source
RGD:620293
See related
EnsemblRapid:ENSRNOG00000014241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ece
Summary
catalyzes the conversion of the big endothelin precursor (big ET-1) to the vasoconstrictive peptide endothelin [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 436.7), Lung (RPKM 390.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ece1 in Genome Data Viewer
Location:
5q36
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150077679..150179375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156215469..156318652)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene U4 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene uncharacterized LOC102553758 Neighboring gene uncharacterized LOC120103013

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel diameter maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bradykinin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in calcitonin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in calcitonin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelin maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelin maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muscle stretch IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in substance P catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in substance P catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Weibel-Palade body IEA
Inferred from Electronic Annotation
more info
 
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endothelin-converting enzyme 1
Names
ECE-1
NP_446048.2
XP_006239337.1
XP_006239338.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053596.2NP_446048.2  endothelin-converting enzyme 1

    See identical proteins and their annotated locations for NP_446048.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072504
    UniProtKB/TrEMBL
    Q6IN10
    Related
    ENSRNOP00000072923.1, ENSRNOT00000077742.2
    Conserved Domains (2) summary
    cd08662
    Location:103752
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:90754
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    150077679..150179375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239275.4XP_006239337.1  endothelin-converting enzyme 1 isoform X1

    Related
    ENSRNOP00000093768.1, ENSRNOT00000108805.1
    Conserved Domains (2) summary
    cd08662
    Location:118767
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:105769
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. XM_006239276.4XP_006239338.1  endothelin-converting enzyme 1 isoform X2

    Related
    ENSRNOP00000095315.1, ENSRNOT00000102078.1
    Conserved Domains (2) summary
    cd08662
    Location:84733
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:71735
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Support Center