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Zfp423 zinc finger protein 423 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94188, updated on 30-Sep-2021

Summary

Official Symbol
Zfp423provided by RGD
Official Full Name
zinc finger protein 423provided by RGD
Primary source
RGD:621664
See related
EnsemblRapid:ENSRNOG00000014658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Roaz; Znf423
Summary
zinc finger protein that interacts with the Olf-1/EBF transcription factor; plays a role in regulation of differentiation of olfactory neurons [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 52.6), Brain (RPKM 50.0) and 9 other tissues See more
Orthologs
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Genomic context

See Zfp423 in Genome Data Viewer
Location:
19p11
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (19111538..19407371)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (20147201..20405999)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene similar to muscle protein684 Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC120098541 Neighboring gene hypothetical protein LOC680913 Neighboring gene uncharacterized LOC102551322

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to cilium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 423
Names
Olf-1/EBF associated Zn finger protein Roaz
olf1/EBF-associated zinc finger protein
smad- and Olf-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393718.1NP_001380647.1  zinc finger protein 423

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000306
    Conserved Domains (2) summary
    COG5048
    Location:202603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:148168
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    19111538..19407371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053583.2: Suppressed sequence

    Description
    NM_053583.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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