U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nans N-acetylneuraminic acid synthase (sialic acid synthase) [ Mus musculus (house mouse) ]

Gene ID: 94181, updated on 3-Jun-2026
Official Symbol
Nansprovided by MGI
Official Full Name
N-acetylneuraminic acid synthase (sialic acid synthase)provided by MGI
Primary source
MGI:MGI:2149820
See related
Ensembl:ENSMUSG00000028334 AllianceGenome:MGI:2149820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sas; 4632418E04Rik
Summary
Enables N-acylneuraminate-9-phosphate synthase activity. Involved in CMP-N-acetylneuraminate biosynthetic process and N-acetylneuraminate metabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; early conceptus; sensory organ; skeleton; and tarsus. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in colon adult (RPKM 145.1), genital fat pad adult (RPKM 46.1) and 21 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Nans in Genome Data Viewer
Location:
4 B1; 4 24.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46489319..46503439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46489329..46503438)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hemogen Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene STARR-positive B cell enhancer ABC_E9585 Neighboring gene STARR-positive B cell enhancer ABC_E3487 Neighboring gene predicted gene, 22247 Neighboring gene tripartite motif-containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E3488 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Neurodevelopmental defects in human cortical organoids with N-acetylneuraminic acid synthase mutation. Bu Q, et al. Sci Adv, 2023 Nov 24. PMID 38000033, Free PMC Article
  2. Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase. Fujita A, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17292865
  3. Sialylation is essential for early development in mice. Schwarzkopf M, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11929971, Free PMC Article
  4. Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis. Willems AP, et al. Biochim Biophys Acta Gen Subj, 2019 Oct. PMID 31121216
  5. Sialic acid is a critical fetal defense against maternal complement attack. Abeln M, et al. J Clin Invest, 2019 Jan 2. PMID 30382946, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intracellular localization of this enzyme is regulated not only due to the nuclear localization signal but also two nuclear export signals.
    Title: Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acylneuraminate-9-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylneuraminate-9-phosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylneuraminate-9-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acylneuraminate-9-phosphate synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CMP-N-acetylneuraminate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
N-acetylneuraminate-9-phosphate synthase
Names
N-acetylneuraminic acid 9-phosphate synthetase
N-acetylneuraminic acid phosphate synthase
sialic acid synthase
NP_001406232.1
NP_001406233.1
NP_001406234.1
NP_444409.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419303.1 → NP_001406232.1  N-acetylneuraminate-9-phosphate synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683884
    UniProtKB/TrEMBL
    Q3TFB5

  2. NM_001419304.1 → NP_001406233.1  N-acetylneuraminate-9-phosphate synthase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL683884

  3. NM_001419305.1 → NP_001406234.1  N-acetylneuraminate-9-phosphate synthase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL683884

  4. NM_053179.4 → NP_444409.1  N-acetylneuraminate-9-phosphate synthase isoform 1

    See identical proteins and their annotated locations for NP_444409.1

    Status: VALIDATED

    Source sequence(s)
    AL683884
    Consensus CDS
    CCDS18152.1
    UniProtKB/Swiss-Prot
    Q99J77, Q9JJH0
    Related
    ENSMUSP00000030018.5, ENSMUST00000030018.5
    Conserved Domains (2) summary
    cd11615
    Location:292 → 348
    SAF_NeuB_like; C-terminal SAF domain of sialic acid synthetase
    pfam03102
    Location:40 → 278
    NeuB; NeuB family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46489319..46503439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J77.1 GenPept UniProtKB/Swiss-Prot:Q99J77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous