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Dock2 dedicator of cyto-kinesis 2 [ Mus musculus (house mouse) ]

Gene ID: 94176, updated on 31-Mar-2024

Summary

Official Symbol
Dock2provided by MGI
Official Full Name
dedicator of cyto-kinesis 2provided by MGI
Primary source
MGI:MGI:2149010
See related
Ensembl:ENSMUSG00000020143 AllianceGenome:MGI:2149010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hch; MBC; CED-5
Summary
Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 15.3), thymus adult (RPKM 14.5) and 11 other tissues See more
Orthologs
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Genomic context

See Dock2 in Genome Data Viewer
Location:
11 A4; 11 19.68 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (34176815..34674732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (34226815..34783905, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12121 Neighboring gene forkhead box I1 Neighboring gene RIKEN cDNA 4930403D09 gene Neighboring gene STARR-seq mESC enhancer starr_29144 Neighboring gene STARR-seq mESC enhancer starr_29145 Neighboring gene inhibitory synaptic factor family member 2B Neighboring gene STARR-seq mESC enhancer starr_29147 Neighboring gene STARR-seq mESC enhancer starr_29148 Neighboring gene STARR-seq mESC enhancer starr_29150 Neighboring gene STARR-positive B cell enhancer mm9_chr11:34444797-34445098 Neighboring gene predicted gene, 29887 Neighboring gene predicted gene, 39681 Neighboring gene STARR-positive B cell enhancer mm9_chr11:34495264-34495565 Neighboring gene STARR-seq mESC enhancer starr_29152 Neighboring gene predicted gene, 51858 Neighboring gene STARR-positive B cell enhancer ABC_E5215 Neighboring gene STARR-positive B cell enhancer ABC_E2983 Neighboring gene STARR-seq mESC enhancer starr_29153 Neighboring gene predicted gene, 53681 Neighboring gene STARR-positive B cell enhancer ABC_E3939 Neighboring gene spindle apparatus coiled-coil protein 1 Neighboring gene predicted gene, 22022

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (19) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macropinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membrane raft polarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid dendritic cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Rac protein signal transduction IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dedicator of cytokinesis protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033374.3NP_203538.2  dedicator of cytokinesis protein 2

    See identical proteins and their annotated locations for NP_203538.2

    Status: VALIDATED

    Source sequence(s)
    AK037611, AK172915, BC040427, CR392356
    Consensus CDS
    CCDS83791.1
    UniProtKB/Swiss-Prot
    Q5SRI4, Q8C3J5, Q99M79
    UniProtKB/TrEMBL
    Q6A0A3
    Related
    ENSMUSP00000090884.6, ENSMUST00000093193.12
    Conserved Domains (4) summary
    cd11706
    Location:11991619
    DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
    pfam16172
    Location:78414
    DOCK_N; DOCK N-terminus
    cl14603
    Location:422617
    C2; C2 domain
    cl17036
    Location:1267
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    34176815..34674732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314862.3XP_017170351.1  dedicator of cytokinesis protein 2 isoform X1

    UniProtKB/TrEMBL
    Q6A0A3
    Conserved Domains (3) summary
    cd11706
    Location:8951315
    DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
    pfam16172
    Location:12110
    DOCK_N; DOCK N-terminus
    cl14603
    Location:118313
    C2; C2 domain