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Prdx6 peroxiredoxin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94167, updated on 2-Oct-2018

Summary

Official Symbol
Prdx6provided by RGD
Official Full Name
peroxiredoxin 6provided by RGD
Primary source
RGD:71005
See related
Ensembl:ENSRNOG00000002896 Vega:OTTRNOG00000000189
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the catabolism of hydrogen peroxide and organic hydroperoxides [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 1481.6), Heart (RPKM 904.1) and 9 other tissues See more
Orthologs

Genomic context

See Prdx6 in Genome Data Viewer
Location:
13q22
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79077567..79088113, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (83972564..83983110, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene solute carrier family 9, member C2 (putative) Neighboring gene uncharacterized LOC102552207 Neighboring gene similar to Actin, cytoplasmic 2 (Gamma-actin) Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bleb assembly ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerophospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-6
Names
1-Cys PRX
1-Cys peroxiredoxin
NSGPx
acidic calcium-independent phospholipase A2
aiPLA2
antioxidant protein 2
non-selenium glutathione peroxidase
thiol-specific antioxidant protein
NP_446028.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053576.2NP_446028.1  peroxiredoxin-6

    See identical proteins and their annotated locations for NP_446028.1

    Status: PROVISIONAL

    Source sequence(s)
    AF014009
    UniProtKB/Swiss-Prot
    O35244
    Related
    ENSRNOP00000030323.4, OTTRNOP00000000136, ENSRNOT00000034583.6, OTTRNOT00000000270
    Conserved Domains (2) summary
    COG0450
    Location:5200
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03016
    Location:7222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    79077567..79088113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    73317100..73327649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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