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SYTL5 synaptotagmin like 5 [ Homo sapiens (human) ]

Gene ID: 94122, updated on 23-Nov-2021

Summary

Official Symbol
SYTL5provided by HGNC
Official Full Name
synaptotagmin like 5provided by HGNC
Primary source
HGNC:HGNC:15589
See related
Ensembl:ENSG00000147041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
slp5
Summary
The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in stomach (RPKM 4.3), placenta (RPKM 2.5) and 17 other tissues See more
Orthologs
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Genomic context

See SYTL5 in Genome Data Viewer
Location:
Xp11.4
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (37888915..38128820)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37865806..37988073)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 3 Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene sterol-C4-methyl oxidase pseudogene Neighboring gene H2A.L variant histone 3 Neighboring gene microRNA 548aj-2 Neighboring gene H2A.P histone Neighboring gene sushi repeat containing protein X-linked Neighboring gene retinitis pigmentosa GTPase regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AL121578.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-like protein 5
Names
exophilin 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013265.1 RefSeqGene

    Range
    4972..127235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163334.1NP_001156806.1  synaptotagmin-like protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001156806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an in-frame coding exon missing in variant 1, resulting in a longer isoform (2) with an additional 22 aa protein segment compared to isoform 1.
    Source sequence(s)
    AK125106, AL135038, BC131585, BX647688
    Consensus CDS
    CCDS55399.1
    UniProtKB/Swiss-Prot
    Q8TDW5
    Related
    ENSP00000395220.2, ENST00000456733.2
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
  2. NM_001163335.2NP_001156807.1  synaptotagmin-like protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001156807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB080222, AK125106, AL121578, AL135038, BX647688
    Consensus CDS
    CCDS14244.1
    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (3) summary
    cd04020
    Location:544722
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:407530
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
  3. NM_138780.3NP_620135.1  synaptotagmin-like protein 5 isoform 1

    See identical proteins and their annotated locations for NP_620135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB080222, AK125106, AL121578, AL135038, BX647688
    Consensus CDS
    CCDS14244.1
    UniProtKB/Swiss-Prot
    Q8TDW5
    Related
    ENSP00000297875.2, ENST00000297875.7
    Conserved Domains (3) summary
    cd04020
    Location:544722
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:407530
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    37888915..38128820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029972.1XP_016885461.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
  2. XM_011544001.2XP_011542303.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011542303.1

    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
  3. XM_017029974.1XP_016885463.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
  4. XM_011544002.2XP_011542304.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011542304.1

    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
  5. XM_017029973.1XP_016885462.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8TDW5
    Conserved Domains (5) summary
    cd04020
    Location:566744
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:429552
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    pfam15308
    Location:159309
    CEP170_C; CEP170 C-terminus
    cl22851
    Location:11123
    PHD_SF; PHD finger superfamily
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