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Csmd1 CUB and Sushi multiple domains 1 [ Mus musculus (house mouse) ]

Gene ID: 94109, updated on 5-Aug-2022

Summary

Official Symbol
Csmd1provided by MGI
Official Full Name
CUB and Sushi multiple domains 1provided by MGI
Primary source
MGI:MGI:2137383
See related
Ensembl:ENSMUSG00000060924 AllianceGenome:MGI:2137383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1890; B930082H09
Summary
Acts upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; cerebral cortex; dorsal root ganglion; main olfactory bulb; and spinal cord. Used to study schizophrenia. Orthologous to human CSMD1 (CUB and Sushi multiple domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.0), frontal lobe adult (RPKM 1.5) and 10 other tissues See more
Orthologs
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Genomic context

See Csmd1 in Genome Data Viewer
Location:
8; 8 A1.1- A1.3
Exon count:
71
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15942538..17586908, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15892538..17535385, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (15892545..17535385, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46033 Neighboring gene chromobox 1 pseudogene Neighboring gene predicted gene, 46073 Neighboring gene microRNA 3106 Neighboring gene predicted gene, 53402 Neighboring gene predicted gene 16347 Neighboring gene predicted gene, 18319 Neighboring gene predicted gene, 25278 Neighboring gene predicted gene, 39136 Neighboring gene predicted gene, 39137 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

Markers

Homology

Clone Names

  • KIAA1890

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CUB and sushi domain-containing protein 1
Names
CUB and sushi multiple domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053171.2NP_444401.2  CUB and sushi domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_444401.2

    Status: VALIDATED

    Source sequence(s)
    AC101229, AC154107, AK081081, AK134585, AK220429, AY017475
    Consensus CDS
    CCDS40244.1
    UniProtKB/Swiss-Prot
    Q8BYQ3, Q923L3
    UniProtKB/TrEMBL
    Q5DTU1
    Related
    ENSMUSP00000080751.7, ENSMUST00000082104.7
    Conserved Domains (5) summary
    cd00033
    Location:26802734
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:20872142
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:26192855
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:758865
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:29783032
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    15942538..17586908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508931.5XP_006508994.2  CUB and sushi domain-containing protein 1 isoform X2

    Conserved Domains (4) summary
    cd00033
    Location:563617
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:21232178
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:26552891
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:794901
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  2. XM_036154398.1XP_036010291.1  CUB and sushi domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    cd00033
    Location:563617
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:21232178
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:26552891
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:794901
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  3. XM_030243874.1XP_030099734.1  CUB and sushi domain-containing protein 1 isoform X4

    Conserved Domains (6) summary
    cd00033
    Location:16811734
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:909964
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:14411677
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:273378
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:10801137
    Sushi; Sushi repeat (SCR repeat)
    cl00049
    Location:433
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  4. XM_036154399.1XP_036010292.1  CUB and sushi domain-containing protein 1 isoform X3

    Conserved Domains (4) summary
    cd00033
    Location:563617
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:21232178
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:24882653
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:794901
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.