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SFXN1 sideroflexin 1 [ Homo sapiens (human) ]

Gene ID: 94081, updated on 4-Oct-2020

Summary

Official Symbol
SFXN1provided by HGNC
Official Full Name
sideroflexin 1provided by HGNC
Primary source
HGNC:HGNC:16085
See related
Ensembl:ENSG00000164466 MIM:615569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCC; SLC56A1
Expression
Ubiquitous expression in liver (RPKM 20.2), kidney (RPKM 17.3) and 24 other tissues See more
Orthologs

Genomic context

See SFXN1 in Genome Data Viewer
Location:
5q35.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (175478560..175529742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174905514..174956745)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 6 Neighboring gene dopamine receptor D1 Neighboring gene RN7SK pseudogene 148 Neighboring gene uncharacterized LOC105377743 Neighboring gene Sharpr-MPRA regulatory region 12912 Neighboring gene histamine receptor H2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12876

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
L-serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
D-serine transport IDA
Inferred from Direct Assay
more info
PubMed 
L-serine transport IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
iron ion transport IEA
Inferred from Electronic Annotation
more info
 
mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
one-carbon metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sideroflexin-1
Names
tricarboxylate carrier protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322977.2NP_001309906.1  sideroflexin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Consensus CDS
    CCDS4394.1
    UniProtKB/Swiss-Prot
    Q9H9B4
    Conserved Domains (1) summary
    pfam03820
    Location:16322
    Mtc; Tricarboxylate carrier
  2. NM_001322978.2NP_001309907.1  sideroflexin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Conserved Domains (1) summary
    pfam03820
    Location:1261
    Mtc; Tricarboxylate carrier
  3. NM_001322980.2NP_001309909.1  sideroflexin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091393
  4. NM_001322981.2NP_001309910.1  sideroflexin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091393
  5. NM_001322982.2NP_001309911.1  sideroflexin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Conserved Domains (1) summary
    pfam03820
    Location:1261
    Mtc; Tricarboxylate carrier
  6. NM_001322983.2NP_001309912.1  sideroflexin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091393
  7. NM_022754.7NP_073591.2  sideroflexin-1 isoform 1

    See identical proteins and their annotated locations for NP_073591.2

    Status: VALIDATED

    Source sequence(s)
    AC091393, AK022938, BC063241, BP199230, BU689165, CN480623
    Consensus CDS
    CCDS4394.1
    UniProtKB/Swiss-Prot
    Q9H9B4
    Related
    ENSP00000316905.5, ENST00000321442.10
    Conserved Domains (1) summary
    pfam03820
    Location:16322
    Mtc; Tricarboxylate carrier

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    175478560..175529742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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