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SFXN1 sideroflexin 1 [ Homo sapiens (human) ]

Gene ID: 94081, updated on 22-Sep-2022

Summary

Official Symbol
SFXN1provided by HGNC
Official Full Name
sideroflexin 1provided by HGNC
Primary source
HGNC:HGNC:16085
See related
Ensembl:ENSG00000164466 MIM:615569; AllianceGenome:HGNC:16085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCC; SLC56A1
Summary
Enables D-serine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in D-serine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 20.2), kidney (RPKM 17.3) and 24 other tissues See more
Orthologs
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Genomic context

See SFXN1 in Genome Data Viewer
Location:
5q35.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175478560..175529742)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176022352..176073526)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174905563..174956745)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene dopamine receptor D1 Neighboring gene Sharpr-MPRA regulatory region 8396 Neighboring gene RN7SK pseudogene 148

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12876

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in L-alanine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-serine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of one-carbon metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in serine import into mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sideroflexin-1
Names
tricarboxylate carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322977.2NP_001309906.1  sideroflexin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Consensus CDS
    CCDS4394.1
    UniProtKB/Swiss-Prot
    Q9H9B4, Q9HA53
    Conserved Domains (1) summary
    pfam03820
    Location:10322
    Mtc; Tricarboxylate carrier
  2. NM_001322978.2NP_001309907.1  sideroflexin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Conserved Domains (1) summary
    pfam03820
    Location:2261
    Mtc; Tricarboxylate carrier
  3. NM_001322980.2NP_001309909.1  sideroflexin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091393
  4. NM_001322981.2NP_001309910.1  sideroflexin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091393
  5. NM_001322982.2NP_001309911.1  sideroflexin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Conserved Domains (1) summary
    pfam03820
    Location:2261
    Mtc; Tricarboxylate carrier
  6. NM_001322983.2NP_001309912.1  sideroflexin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091393
    Conserved Domains (1) summary
    pfam03820
    Location:10241
    Mtc; Tricarboxylate carrier
  7. NM_022754.7NP_073591.2  sideroflexin-1 isoform 1

    See identical proteins and their annotated locations for NP_073591.2

    Status: VALIDATED

    Source sequence(s)
    AC091393, AK022938, BC063241, BP199230, BU689165, CN480623
    Consensus CDS
    CCDS4394.1
    UniProtKB/Swiss-Prot
    Q9H9B4, Q9HA53
    Related
    ENSP00000316905.5, ENST00000321442.10
    Conserved Domains (1) summary
    pfam03820
    Location:10322
    Mtc; Tricarboxylate carrier

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    175478560..175529742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    176022352..176073526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)