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P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 [ Mus musculus (house mouse) ]

Gene ID: 94045, updated on 5-Jul-2025
Official Symbol
P2rx5provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 5provided by MGI
Primary source
MGI:MGI:2137026
See related
Ensembl:ENSMUSG00000005950 AllianceGenome:MGI:2137026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2X5
Summary
Enables extracellularly ATP-gated monoatomic cation channel activity and ligand-gated monoatomic anion channel activity. Involved in chloride transport and osteoclast maturation. Predicted to be located in membrane and postsynapse. Predicted to be active in plasma membrane. Is expressed in several structures, including forelimb bud; nervous system; neural ectoderm; olfactory epithelium; and retina. Orthologous to human P2RX5 (purinergic receptor P2X 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in heart adult (RPKM 2.0), mammary gland adult (RPKM 2.0) and 21 other tissues See more
Orthologs
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See P2rx5 in Genome Data Viewer
Location:
11 B4; 11 45.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73029164..73063509)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73155389..73172687)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene ER membrane protein complex subunit 6

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3) 

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pH IEA
Inferred from Electronic Annotation
more info
 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
P2X purinoceptor 5
Names
purinergic receptor P2X5-2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376982.1NP_001363911.1  P2X purinoceptor 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    B7ZND5
    Conserved Domains (1) summary
    TIGR00863
    Location:1373
    P2X; cation transporter protein
  2. NM_001376983.1NP_001363912.1  P2X purinoceptor 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    B7ZND5
    Related
    ENSMUSP00000121834.2, ENSMUST00000136894.3
    Conserved Domains (1) summary
    TIGR00863
    Location:1373
    P2X; cation transporter protein
  3. NM_001424833.1NP_001411762.1  P2X purinoceptor 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670399
  4. NM_001425088.1NP_001412017.1  P2X purinoceptor 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL670399
  5. NM_001425089.1NP_001412018.1  P2X purinoceptor 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670399
  6. NM_033321.4NP_201578.2  P2X purinoceptor 5 isoform 1

    See identical proteins and their annotated locations for NP_201578.2

    Status: VALIDATED

    Source sequence(s)
    AL670399
    Consensus CDS
    CCDS24998.1
    UniProtKB/Swiss-Prot
    B9EHM6, Q3UYI1, Q91VE2
    UniProtKB/TrEMBL
    B7ZND5
    Related
    ENSMUSP00000006104.4, ENSMUST00000006104.10
    Conserved Domains (1) summary
    TIGR00863
    Location:1373
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73029164..73063509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)