P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2rx5provided by MGI
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 5provided by MGI
Primary source: MGI:MGI:2137026
See related: Ensembl:ENSMUSG00000005950 AllianceGenome:MGI:2137026
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2X5
Summary: Enables extracellularly ATP-gated monoatomic cation channel activity and ligand-gated monoatomic anion channel activity. Involved in chloride transport and osteoclast maturation. Predicted to be located in membrane and postsynapse. Predicted to be active in plasma membrane. Is expressed in several structures, including forelimb bud; nervous system; neural ectoderm; olfactory epithelium; and retina. Orthologous to human P2RX5 (purinergic receptor P2X 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in heart adult (RPKM 2.0), mammary gland adult (RPKM 2.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.25 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (73029164..73063509)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73155389..73172687)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes.
Title: Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes.
Results identify P2X5 as highly expressed during the osteoclasts (OCs) maturation phase and demonstrate that P2X5 is required for ATP-mediated inflammasome activation and IL-1beta production by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous IL-1beta.
Title: The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts.
The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Real-time PCR showed that P2XRs except P2X5R were expressed in Bone Marrow and spleen macrophages.
Title: Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia.
transient high expression pattern of P2X5 receptors in epithelium-like structures suggests a role during early neurogenesis
Title: Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems.
This study provides the first evidence that P2X5 receptors are expressed on LHRH-containing neurons.
Title: P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
The identification of extensive P2X5 receptor immunoreactivity and mRNA distribution within the CNS of the mouse demonstrated here is consistent with a role for extracellular ATP acting as a fast neurotransmitter.
Title: Expression of P2X5 receptors in the mouse CNS.
Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina.
Title: Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.
sequential expression of the P2X5, P2Y1, and P2X2 receptors during the process of muscle regeneration
Title: Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP-gated ion channel activity	IEA Inferred from Electronic Annotation more info
enables ATP-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in osteoclast maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in regulation of skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to pH	IEA Inferred from Electronic Annotation more info
involved_in response to pH	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	IEA Inferred from Electronic Annotation more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2X purinoceptor 5

Names: purinergic receptor P2X5-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376982.1 → NP_001363911.1 P2X purinoceptor 5 isoform 2

Status: VALIDATED

Source sequence(s)

AL670399

UniProtKB/TrEMBL

B7ZND5

Conserved Domains (1) summary

TIGR00863
Location:1 → 373

P2X; cation transporter protein
NM_001376983.1 → NP_001363912.1 P2X purinoceptor 5 isoform 3

Status: VALIDATED

Source sequence(s)

AL670399

UniProtKB/TrEMBL

B7ZND5

Related

ENSMUSP00000121834.2, ENSMUST00000136894.3

Conserved Domains (1) summary

TIGR00863
Location:1 → 373

P2X; cation transporter protein
NM_001424833.1 → NP_001411762.1 P2X purinoceptor 5 isoform 4

Status: VALIDATED

Source sequence(s)

AL670399
NM_001425088.1 → NP_001412017.1 P2X purinoceptor 5 isoform 5

Status: VALIDATED

Source sequence(s)

AL670399
NM_001425089.1 → NP_001412018.1 P2X purinoceptor 5 isoform 2

Status: VALIDATED

Source sequence(s)

AL670399
NM_033321.4 → NP_201578.2 P2X purinoceptor 5 isoform 1

See identical proteins and their annotated locations for NP_201578.2

Status: VALIDATED

Source sequence(s)

AL670399

Consensus CDS

CCDS24998.1

UniProtKB/Swiss-Prot

B9EHM6, Q3UYI1, Q91VE2

UniProtKB/TrEMBL

B7ZND5

Related

ENSMUSP00000006104.4, ENSMUST00000006104.10

Conserved Domains (1) summary

TIGR00863
Location:1 → 373

P2X; cation transporter protein