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ZNF101 zinc finger protein 101 [ Homo sapiens (human) ]

Gene ID: 94039, updated on 11-Jun-2021

Summary

Official Symbol
ZNF101provided by HGNC
Official Full Name
zinc finger protein 101provided by HGNC
Primary source
HGNC:HGNC:12881
See related
Ensembl:ENSG00000181896 MIM:603983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF12
Summary
Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]
Expression
Broad expression in lymph node (RPKM 7.9), appendix (RPKM 4.5) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF101 in Genome Data Viewer
Location:
19p13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (19668070..19683506)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19778962..19794315)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GEM interacting protein Neighboring gene ATPase 13A1 Neighboring gene conserved acetylation island sequence C14 enhancer Neighboring gene zinc finger protein 14 Neighboring gene uncharacterized LOC101060187 Neighboring gene sorting nexin 18 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
GeneReviews: Not available
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
GeneReviews: Not available
Genome-wide association study of selenium concentrations.
GeneReviews: Not available
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149565, MGC149566, DKFZp570I0164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 101
Names
zinc finger protein 101 (Y2)
zinc finger protein 12
zinc finger protein HZF12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300949.2NP_001287878.1  zinc finger protein 101 isoform 2

    See identical proteins and their annotated locations for NP_001287878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC011458, AY149174, BM972114, DB264378
    Consensus CDS
    CCDS77271.1
    UniProtKB/Swiss-Prot
    Q8IZC7
    Conserved Domains (2) summary
    COG5048
    Location:56237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_033204.4NP_149981.2  zinc finger protein 101 isoform 1

    See identical proteins and their annotated locations for NP_149981.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011458, AY149174, BM972114, CR999939
    Consensus CDS
    CCDS32971.1
    UniProtKB/Swiss-Prot
    Q8IZC7
    Related
    ENSP00000468049.1, ENST00000592502.2
    Conserved Domains (6) summary
    cd11674
    Location:149209
    lambda-1; inner capsid protein lambda-1 or VP3
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:176357
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:340360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:240264
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    19668070..19683506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451787.1XP_024307555.1  zinc finger protein 101 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:56237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_024451786.1XP_024307554.1  zinc finger protein 101 isoform X1

    Related
    ENSP00000400952.2, ENST00000415784.6
    Conserved Domains (2) summary
    COG5048
    Location:56237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_024451785.1XP_024307553.1  zinc finger protein 101 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:56237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
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