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FTMT ferritin mitochondrial [ Homo sapiens (human) ]

Gene ID: 94033, updated on 7-Jul-2022

Summary

Official Symbol
FTMTprovided by HGNC
Official Full Name
ferritin mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:17345
See related
Ensembl:ENSG00000181867 MIM:608847; AllianceGenome:HGNC:17345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTF
Summary
Predicted to enable ferric iron binding activity and ferrous iron binding activity. Involved in several processes, including cellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See FTMT in Genome Data Viewer
Location:
5q23.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (121851882..121852833)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (122368749..122369700)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121187577..121188528)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 pseudogene 10 Neighboring gene uncharacterized LOC105379150 Neighboring gene uncharacterized LOC105379149 Neighboring gene uncharacterized LOC105379148 Neighboring gene serum response factor binding protein 1 Neighboring gene lysyl oxidase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog
Genetic variation modifies risk for neurodegeneration based on biomarker status.
EBI GWAS Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
ferritin, mitochondrial
Names
ferritin H subunit
mitochondrial ferritin
NP_803431.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177478.2NP_803431.1  ferritin, mitochondrial precursor

    See identical proteins and their annotated locations for NP_803431.1

    Status: VALIDATED

    Source sequence(s)
    AC117523, BC034419
    Consensus CDS
    CCDS4128.1
    UniProtKB/Swiss-Prot
    Q8N4E7
    Related
    ENSP00000313691.1, ENST00000321339.3
    Conserved Domains (2) summary
    cd01056
    Location:73233
    Euk_Ferritin; eukaryotic ferritins
    pfam00210
    Location:77218
    Ferritin; Ferritin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    121851882..121852833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    122368749..122369700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)