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HTRA3 HtrA serine peptidase 3 [ Homo sapiens (human) ]

Gene ID: 94031, updated on 13-Mar-2020

Summary

Official Symbol
HTRA3provided by HGNC
Official Full Name
HtrA serine peptidase 3provided by HGNC
Primary source
HGNC:HGNC:30406
See related
Ensembl:ENSG00000170801 MIM:608785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Prsp; Tasp
Expression
Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues See more
Orthologs

Genomic context

See HTRA3 in Genome Data Viewer
Location:
4p16.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (8269712..8307098)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8271487..8308838)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene guanine monophosphate synthase pseudogene 1 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC105374373 Neighboring gene uncharacterized LOC112268463 Neighboring gene long intergenic non-protein coding RNA 2517 Neighboring gene acyl-CoA oxidase 3, pristanoyl Neighboring gene RNA, 5S ribosomal pseudogene 152

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease HTRA3
Names
high-temperature requirement factor A3
pregnancy-related serine protease
probable serine protease HTRA3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297559.2NP_001284488.1  serine protease HTRA3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus.
    Source sequence(s)
    AC113611, AW072765, AY280666, DN996853
    Consensus CDS
    CCDS75105.1
    UniProtKB/Swiss-Prot
    P83110
    Related
    ENSP00000371952.3, ENST00000382512.3
    Conserved Domains (3) summary
    pfam00219
    Location:2576
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:81126
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:175319
    Trypsin_2; Trypsin-like peptidase domain
  2. NM_053044.5NP_444272.1  serine protease HTRA3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_444272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113611, BC035717
    Consensus CDS
    CCDS3400.1
    UniProtKB/Swiss-Prot
    P83110
    Related
    ENSP00000303766.2, ENST00000307358.7
    Conserved Domains (4) summary
    cd00987
    Location:355440
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00219
    Location:2576
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:81126
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:175319
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    8269712..8307098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513596.3XP_011511898.1  serine protease HTRA3 isoform X1

    Conserved Domains (3) summary
    pfam00219
    Location:2576
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:81126
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:175319
    Trypsin_2; Trypsin-like peptidase domain
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