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LRRC4B leucine rich repeat containing 4B [ Homo sapiens (human) ]

Gene ID: 94030, updated on 1-Aug-2020

Summary

Official Symbol
LRRC4Bprovided by HGNC
Official Full Name
leucine rich repeat containing 4Bprovided by HGNC
Primary source
HGNC:HGNC:25042
See related
Ensembl:ENSG00000131409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSM; LRIG4; NGL-3
Expression
Biased expression in brain (RPKM 11.1), endometrium (RPKM 2.3) and 4 other tissues See more
Orthologs

Genomic context

See LRRC4B in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (50516892..50568435, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51020149..51071302, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 2 Neighboring gene aspartate dehydrogenase domain containing Neighboring gene CRISPRi-validated cis-regulatory element chr19.5650 Neighboring gene small NF90 (ILF3) associated RNA F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761A179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 4B
Names
leucine-rich repeats and immunoglobulin-like domains 4
netrin-G3 ligand

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080457.2NP_001073926.1  leucine-rich repeat-containing protein 4B precursor

    See identical proteins and their annotated locations for NP_001073926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008743
    Consensus CDS
    CCDS42595.1
    UniProtKB/Swiss-Prot
    Q9NT99
    UniProtKB/TrEMBL
    A0A024R4I8
    Related
    ENSP00000498662.1, ENST00000652263.1
    Conserved Domains (5) summary
    smart00013
    Location:5790
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:311361
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:76297
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:364453
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:88111
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001348568.1NP_001335497.1  leucine-rich repeat-containing protein 4B precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008743
    Consensus CDS
    CCDS42595.1
    UniProtKB/Swiss-Prot
    Q9NT99
    UniProtKB/TrEMBL
    A0A024R4I8
    Related
    ENSP00000471502.1, ENST00000599957.5
    Conserved Domains (5) summary
    smart00013
    Location:5790
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:311361
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:76297
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:364453
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:88111
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    50516892..50568435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723506.3XP_006723569.1  leucine-rich repeat-containing protein 4B isoform X1

    See identical proteins and their annotated locations for XP_006723569.1

    UniProtKB/Swiss-Prot
    Q9NT99
    UniProtKB/TrEMBL
    A0A024R4I8
    Conserved Domains (5) summary
    smart00013
    Location:5790
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:311361
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:76297
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:364453
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:88111
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011527520.3XP_011525822.1  leucine-rich repeat-containing protein 4B isoform X1

    See identical proteins and their annotated locations for XP_011525822.1

    UniProtKB/Swiss-Prot
    Q9NT99
    UniProtKB/TrEMBL
    A0A024R4I8
    Conserved Domains (5) summary
    smart00013
    Location:5790
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:311361
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:76297
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:364453
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:88111
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_005259429.5XP_005259486.1  leucine-rich repeat-containing protein 4B isoform X1

    See identical proteins and their annotated locations for XP_005259486.1

    UniProtKB/Swiss-Prot
    Q9NT99
    UniProtKB/TrEMBL
    A0A024R4I8
    Conserved Domains (5) summary
    smart00013
    Location:5790
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:311361
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:76297
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:364453
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:88111
    LRR_RI; leucine-rich repeat [structural motif]
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