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CGB7 chorionic gonadotropin subunit beta 7 [ Homo sapiens (human) ]

Gene ID: 94027, updated on 5-Sep-2021

Summary

Official Symbol
CGB7provided by HGNC
Official Full Name
chorionic gonadotropin subunit beta 7provided by HGNC
Primary source
HGNC:HGNC:16451
See related
Ensembl:ENSG00000196337 MIM:608826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGB6; CG-beta-a
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 5.5), skin (RPKM 1.3) and 1 other tissue See more
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Genomic context

See CGB7 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49054274..49057749, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49557531..49561006, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 pseudogene Neighboring gene chorionic gonadotropin subunit beta 8 Neighboring gene neurotrophin 4 Neighboring gene potassium voltage-gated channel subfamily A member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ35403, FLJ43118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in female gamete generation TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
choriogonadotropin subunit beta 7
Names
chorionic gonadotropin beta 7 subunit
chorionic gonadotropin beta subunit 7
chorionic gonadotropin, beta polypeptide 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385261.1NP_001372190.1  choriogonadotropin subunit beta 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008687
    Related
    ENSP00000507822.1, ENST00000684222.1
    Conserved Domains (1) summary
    smart00068
    Location:25131
    GHB; Glycoprotein hormone beta chain homologues
  2. NM_033142.2NP_149133.1  choriogonadotropin subunit beta 7 precursor

    See identical proteins and their annotated locations for NP_149133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS33071.1
    UniProtKB/Swiss-Prot
    P0DN87
    UniProtKB/TrEMBL
    A0A0F7RQF0
    Related
    ENSP00000469076.1, ENST00000596965.5
    Conserved Domains (1) summary
    smart00068
    Location:25131
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49054274..49057749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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