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GRAP2 GRB2 related adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 9402, updated on 18-Aug-2020

Summary

Official Symbol
GRAP2provided by HGNC
Official Full Name
GRB2 related adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:4563
See related
Ensembl:ENSG00000100351 MIM:604518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
Summary
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Expression
Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues See more
Orthologs

Genomic context

See GRAP2 in Genome Data Viewer
Location:
22q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (39901073..39973721)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (40297086..40369347)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ENTH domain containing 1 Neighboring gene RN7SK pseudogene 210 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene uncharacterized LOC114841040 Neighboring gene family with sequence similarity 83 member F Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene ribosomal protein L7 pseudogene 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
GRB2-related adapter protein 2
Names
GRB-2-like protein
GRB2-related protein with insert domain
SH3-SH2-SH3 adapter Mona
SH3-SH2-SH3 adaptor molecule
adapter protein GRID
grf-40
grf40 adapter protein
growth factor receptor-binding protein
growth factor receptor-bound protein 2-related adaptor protein 2
hematopoietic cell-associated adapter protein GrpL
hematopoietic cell-associated adaptor protein GRPL

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291824.2NP_001278753.1  GRB2-related adapter protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001278753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AK312830, DC409651, KF457461, Z82206
    Consensus CDS
    CCDS13999.1
    UniProtKB/Swiss-Prot
    O75791
    UniProtKB/TrEMBL
    Q6FI14
    Conserved Domains (3) summary
    cd09941
    Location:54147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11947
    Location:253
    SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cd11950
    Location:275327
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
  2. NM_001291825.1NP_001278754.1  GRB2-related adapter protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001278754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
    Source sequence(s)
    AF236120, Z82206
    Consensus CDS
    CCDS13999.1
    UniProtKB/Swiss-Prot
    O75791
    UniProtKB/TrEMBL
    Q6FI14
    Related
    ENSP00000385607.3, ENST00000407075.3
    Conserved Domains (3) summary
    cd09941
    Location:54147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11947
    Location:253
    SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cd11950
    Location:275327
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
  3. NM_001291826.2NP_001278755.1  GRB2-related adapter protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001278755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303280, DC409651, KF457461, Z82206
    UniProtKB/TrEMBL
    B7Z8E3
    Conserved Domains (2) summary
    cd09941
    Location:375
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11950
    Location:203255
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
  4. NM_001291828.2NP_001278757.1  GRB2-related adapter protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001278757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three internal exons, which results in an alternate downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303470, HY091328, KF457461, Z82206
    UniProtKB/Swiss-Prot
    O75791
    Conserved Domains (1) summary
    cd11950
    Location:162214
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
  5. NM_004810.4NP_004801.1  GRB2-related adapter protein 2 isoform 1

    See identical proteins and their annotated locations for NP_004801.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
    Source sequence(s)
    AY069959, KF457461, Z82206
    Consensus CDS
    CCDS13999.1
    UniProtKB/Swiss-Prot
    O75791
    UniProtKB/TrEMBL
    Q6FI14
    Related
    ENSP00000339186.4, ENST00000344138.9
    Conserved Domains (3) summary
    cd09941
    Location:54147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11947
    Location:253
    SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cd11950
    Location:275327
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    39901073..39973721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724376.3XP_006724439.1  GRB2-related adapter protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006724439.1

    UniProtKB/TrEMBL
    B7Z8E3
    Conserved Domains (2) summary
    cd09941
    Location:375
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11950
    Location:203255
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
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