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gltC transcriptional regulator (LysR family) (GltC-glutamate) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 940104, updated on 3-Apr-2021

Summary

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Gene symbol
gltC
Gene description
transcriptional regulator (LysR family) (GltC-glutamate)
Locus tag
BSU_18460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU18460
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Genomic context

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Sequence:
NC_000964.3 (2014779..2015681)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene glutamate synthase (small subunit, NADP-dependent) Neighboring gene glutamate synthase (large subunit, NADP-dependent) Neighboring gene glutamate 5-kinase Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene replication terminator protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of the regulation of Bacillus subtilis gltAB expression by GltC. Picossi S, et al. J Mol Biol, 2007 Feb 2. PMID 17134717, Free PMC Article
  2. A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC. Commichau FM, et al. Mol Microbiol, 2007 Aug. PMID 17608797
  3. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  4. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
  5. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The genetic and biochemical data presented here show that the glutamate dehydrogenase RocG is able to bind to and concomitantly inactivate the activator protein GltC.
    Title: A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC.
  2. Active form of GltC requires alpha-ketoglutarate, a substrate of glutamate synthase, to fully activate gltA transcription.
    Title: Molecular mechanism of the regulation of Bacillus subtilis gltAB expression by GltC.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
transcriptional regulator (LysR family) (GltC-glutamate)
NP_389728.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389728.2 transcriptional regulator (LysR family) (GltC-glutamate) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389728.2

    Status: PROVISIONAL

    Conserved Domains (2) summary
    cd08434
    Location:92 → 289
    PBP2_GltC_like; The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold
    pfam00126
    Location:3 → 62
    HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20668.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials