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PIGS phosphatidylinositol glycan anchor biosynthesis class S [ Homo sapiens (human) ]

Gene ID: 94005, updated on 7-Jun-2020

Summary

Official Symbol
PIGSprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Sprovided by HGNC
Primary source
HGNC:HGNC:14937
See related
Ensembl:ENSG00000087111 MIM:610271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPIBD18
Summary
This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 16.8), kidney (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See PIGS in Genome Data Viewer
Location:
17q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28553387..28571524, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26880405..26898887, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene forkhead box N1 Neighboring gene unc-119 lipid binding chaperone Neighboring gene aldolase, fructose-bisphosphate C Neighboring gene sperm associated antigen 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45226, DKFZp686K20216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GPI-anchor transamidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
attachment of GPI anchor to protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
PubMed 
GPI-anchor transamidase complex TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
GPI transamidase component PIG-S
Names
GPI transamidase subunit
phosphatidylinositol glycan, class S
phosphatidylinositol-glycan biosynthesis class S protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033198.4NP_149975.1  GPI transamidase component PIG-S

    See identical proteins and their annotated locations for NP_149975.1

    Status: REVIEWED

    Source sequence(s)
    AC005726, AK075428, AW084841, BC007301
    Consensus CDS
    CCDS11235.1
    UniProtKB/Swiss-Prot
    Q96S52
    UniProtKB/TrEMBL
    Q8NBL9, Q96IR5
    Related
    ENSP00000309430.7, ENST00000308360.8
    Conserved Domains (1) summary
    pfam10510
    Location:22550
    PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28553387..28571524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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