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dnaA chromosomal replication initiator informational ATPase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939978, updated on 10-Oct-2024
Gene symbol
dnaA
Gene description
chromosomal replication initiator informational ATPase
Locus tag
BSU_00010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU00010
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Sequence:
NC_000964.3 (410..1750)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III (beta subunit) Neighboring gene RNA binding protein involved in ribosome maturation

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA. Smith JL, et al. PLoS Genet, 2015 May. PMID 26020636, Free PMC Article
  2. Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA. Jameson KH, et al. Mol Microbiol, 2014 Sep. PMID 25041308, Free PMC Article
  3. Distribution of stable DnaA-binding sites on the Bacillus subtilis genome detected using a modified ChIP-chip method. Ishikawa S, et al. DNA Res, 2007 Aug 31. PMID 17932079, Free PMC Article
  4. DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction. Martin E, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30534966, Free PMC Article
  5. DNA gyrase activity regulates DnaA-dependent replication initiation in Bacillus subtilis. Samadpour AN, et al. Mol Microbiol, 2018 Apr. PMID 29396913, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This in turn suggests that DnaA and DnaD are working collaboratively in the oriC to locally melt the DNA duplex during replication initiation.
    Title: DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction.
  2. DNA gyrase is a negative regulator of DnaA-dependent replication initiation from oriC, and that this regulatory mechanism is required for cell survival.
    Title: DNA gyrase activity regulates DnaA-dependent replication initiation in Bacillus subtilis.
  3. DnaA shows extremely rapid binding turnover on the chromosome including oriC regions in two bacterial species, which is influenced by Soj and YabA proteins in B. subtilis, and is crucial for balanced initiation control, likely preventing fatal premature multimerization and strand opening of DnaA at oriC.
    Title: Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication.
  4. Our in vitro characterization of the inherent ability of DnaA to bind the genome at single nucleotide resolution provides a backdrop for interpreting data on in vivo binding and regulation of DnaA
    Title: In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA.
  5. SirA complex with the N-terminal domain of DnaA and forms heterodimeric complex.
    Title: Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA.
  6. DnaA colocalization with origins is specific to the time of initiation, and replisome/YabA-mediated spatial sequestration of DnaA prevents inappropriate reinitiation of DNA replication
    Title: Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis.
  7. These findings suggest that DnaA plays several additional roles, such as control of the level of effective initiator, ATP-DnaA, and/or stabilization of the domain structure of the genome around oriC for the proper initiation of chromosome replication.
    Title: Distribution of stable DnaA-binding sites on the Bacillus subtilis genome detected using a modified ChIP-chip method.
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Homology

Preferred Names
chromosomal replication initiator informational ATPase
NP_387882.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_387882.1 chromosomal replication initiator informational ATPase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_387882.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAP1H961
    Conserved Domains (1) summary
    TIGR00362
    Location:8 → 445
    DnaA; chromosomal replication initiator protein DnaA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05648.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials