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pbpB penicillin-binding protein 2B [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939847, updated on 4-Apr-2024

Summary

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Gene symbol
pbpB
Gene description
penicillin-binding protein 2B
Locus tag
BSU_15160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU15160
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Genomic context

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Sequence:
NC_000964.3 (1581947..1584097)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene inhibitor of RsmH and transcriptional regulator Neighboring gene 16S rRNA m4C1402 methyltransferase Neighboring gene cell-division protein Neighboring gene transpeptidase penicillin-binding protein Neighboring gene UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PASTA domains of Bacillus subtilis PBP2B strengthen the interaction of PBP2B with DivIB. Morales Angeles D, et al. Microbiology (Reading), 2020 Sep. PMID 32749956, Free PMC Article
  2. Evidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic β domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2B. Rowland SL, et al. J Bacteriol, 2010 Dec. PMID 20870765, Free PMC Article
  3. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  4. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
  5. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PASTA domains of Bacillus subtilis PBP2B strengthen the interaction of PBP2B with DivIB.
    Title: The PASTA domains of Bacillus subtilis PBP2B strengthen the interaction of PBP2B with DivIB.
  2. These experiments revealed that the C-terminal region of the beta domain of DivIB is critical for its interaction with PBP 2B.
    Title: Evidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic β domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2B.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
penicillin-binding protein 2B
NP_389399.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389399.2 penicillin-binding protein 2B [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389399.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q07868
    Conserved Domains (4) summary
    cd06575
    Location:660 → 713
    PASTA_Pbp2x-like_2; PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by ...
    cd06576
    Location:602 → 656
    PASTA_Pbp2x-like_1; PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by ...
    COG0768
    Location:6 → 590
    FtsI; Cell division protein FtsI/penicillin-binding protein 2 [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis]
    sd00037
    Location:602 → 655
    PASTA; PASTA domain [structural motif]
Nucleotide Protein
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Other Literature Sources
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