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NMT2 N-myristoyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 9397, updated on 17-Jun-2019

Summary

Official Symbol
NMT2provided by HGNC
Official Full Name
N-myristoyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:7858
See related
Ensembl:ENSG00000152465 MIM:603801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues See more
Orthologs

Genomic context

See NMT2 in Genome Data Viewer
Location:
10p13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (15104588..15168693, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15147771..15210703, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45 Neighboring gene RPP38 divergent transcript Neighboring gene uncharacterized LOC105376431 Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene uncharacterized LOC107984210 Neighboring gene peptidylprolyl isomerase A pseudogene 30 Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene uncharacterized LOC105376434

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The N-terminal methionine of HIV-1 Nef is myristoylated by N-myristoyltransferase PubMed
matrix gag HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Assembly Of The HIV Virion, organism-specific biosystem (from REACTOME)
    Assembly Of The HIV Virion, organism-specific biosystemVirion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the G...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • Membrane binding and targetting of GAG proteins, organism-specific biosystem (from REACTOME)
    Membrane binding and targetting of GAG proteins, organism-specific biosystemOne of the mysteries of Gag protein involvement in HIV virion assembly is how the proteins are targeted to the proper membrane for budding. Infectious retroviruses do not bud from all of the availabl...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Synthesis And Processing Of GAG, GAGPOL Polyproteins, organism-specific biosystem (from REACTOME)
    Synthesis And Processing Of GAG, GAGPOL Polyproteins, organism-specific biosystemEvidence suggests that the RNA molecules used for the synthesis of Gag and Gag-Pro-Pol are not the same molecules that are packaged into virions. Gag proteins do not appear to aggregate around and ca...
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycylpeptide N-tetradecanoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
N-terminal peptidyl-glycine N-myristoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal peptidyl-glycine N-myristoylation IDA
Inferred from Direct Assay
more info
PubMed 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
host cell IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
glycylpeptide N-tetradecanoyltransferase 2
Names
NMT 2
glycylpeptide N-tetradecanoyltransferase 2 variant 3
glycylpeptide N-tetradecanoyltransferase 2 variant 4
myristoyl-CoA:protein N-myristoyltransferase 2
peptide N-myristoyltransferase 2
type II N-myristoyltransferase
NP_001295224.1
NP_004799.1
XP_005252699.1
XP_006717602.1
XP_016872436.1
XP_016872437.1
XP_016872438.1
XP_016872439.1
XP_016872440.1
XP_024304029.1
XP_024304030.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308295.2NP_001295224.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001295224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF043325, AF086423, AK094904, AL590365, DB465189
    Consensus CDS
    CCDS76284.1
    UniProtKB/Swiss-Prot
    O60551
    UniProtKB/TrEMBL
    B3KT39, Q5VUC6
    Related
    ENSP00000367392.1, ENST00000378150.1
    Conserved Domains (1) summary
    cl27359
    Location:106473
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  2. NM_004808.3NP_004799.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_004799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF043325, AL590365
    Consensus CDS
    CCDS7109.1
    UniProtKB/Swiss-Prot
    O60551
    Related
    ENSP00000367407.3, ENST00000378165.9
    Conserved Domains (1) summary
    cl27359
    Location:119486
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    15104588..15168693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016947.2XP_016872436.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

  2. XM_017016950.2XP_016872439.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

  3. XM_017016948.1XP_016872437.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

  4. XM_024448261.1XP_024304029.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X8

    Conserved Domains (1) summary
    cl27359
    Location:32399
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  5. XM_005252642.5XP_005252699.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    Conserved Domains (2) summary
    pfam01233
    Location:140294
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:310485
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  6. XM_017016949.2XP_016872438.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

  7. XM_024448262.1XP_024304030.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X9

    Conserved Domains (1) summary
    cl27359
    Location:32399
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  8. XM_006717539.4XP_006717602.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

    Conserved Domains (2) summary
    pfam01233
    Location:140256
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:253428
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  9. XM_017016951.2XP_016872440.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X7

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