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desK two-component thermosensor histidine kinase [DesR-DesK] [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939678, updated on 6-Oct-2023
Gene symbol
desK
Gene description
two-component thermosensor histidine kinase [DesR-DesK]
Locus tag
BSU_19190
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU19190
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Sequence:
NC_000964.3 (2090574..2091686)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance) Neighboring gene fatty acid desaturase Neighboring gene two-component response regulator [DesK] Neighboring gene exported cell wall lytic enzyme

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Single Transmembrane Segment of Minimal Sensor DesK Senses Temperature via a Membrane-Thickness Caliper. Inda ME, et al. J Bacteriol, 2016 Nov 1. PMID 27528507, Free PMC Article
  2. Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Albanesi D, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805278, Free PMC Article
  3. A coiled coil switch mediates cold sensing by the thermosensory protein DesK. Saita E, et al. Mol Microbiol, 2015 Oct. PMID 26172072
  4. A lipid-mediated conformational switch modulates the thermosensing activity of DesK. Inda ME, et al. Proc Natl Acad Sci U S A, 2014 Mar 4. PMID 24522108, Free PMC Article
  5. Oligomerization of Bacillus subtilis DesR is required for fine tuning regulation of membrane fluidity. Najle SR, et al. Biochim Biophys Acta, 2009 Oct. PMID 19595746

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The thickness of lipid membranes varies with temperature and that such variations can be detected by DesK with great precision.
    Title: The Single Transmembrane Segment of Minimal Sensor DesK Senses Temperature via a Membrane-Thickness Caliper.
  2. In vivo and biochemical experiments, structural analyses and simulations, demonstrated that stabilization/destabilization of a 2-helix coiled coil is directly involved in regulating DesK's functional state.
    Title: A coiled coil switch mediates cold sensing by the thermosensory protein DesK.
  3. A lipid-mediated conformational switch modulates the thermosensing activity of DesK.
    Title: A lipid-mediated conformational switch modulates the thermosensing activity of DesK.
  4. Data show that the membrane-bound histidine kinase DesK phosphorylates the response regulator DesR to activate des transcription.
    Title: Oligomerization of Bacillus subtilis DesR is required for fine tuning regulation of membrane fluidity.
  5. Data from the structural comparison of the different DesK variants indicates that incoming signals can take the form of helix rotations and asymmetric helical bends similar to those reported for other sensing systems.
    Title: Structural plasticity and catalysis regulation of a thermosensor histidine kinase.
Submit: New GeneRIF Correction

Homology

Preferred Names
two-component thermosensor histidine kinase [DesR-DesK]
NP_389800.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389800.1 two-component thermosensor histidine kinase [DesR-DesK] [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389800.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KQI1
    Conserved Domains (1) summary
    COG4585
    Location:1 → 366
    COG4585; Signal transduction histidine kinase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O34757.1

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