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bdhA acetoin reductase/2,3-butanediol dehydrogenase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939490, updated on 12-Feb-2021

Summary

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Gene symbol
bdhA
Gene description
acetoin reductase/2,3-butanediol dehydrogenase
Locus tag
BSU_06240
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU06240
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Genomic context

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Sequence:
NC_000964.3 (677911..678951, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative membrane associated potassium channel; prophage region 3 Neighboring gene myo-inositol transporter Neighboring gene protein involved in cell wall metabolism Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of deletion of 2,3-butanediol dehydrogenase gene (bdhA) on acetoin production of Bacillus subtilis. Zhang J, et al. Prep Biochem Biotechnol, 2017 Sep 14. PMID 28426331
  2. The rebalanced pathway significantly enhances acetoin production by disruption of acetoin reductase gene and moderate-expression of a new water-forming NADH oxidase in Bacillus subtilis. Zhang X, et al. Metab Eng, 2014 May. PMID 24525333
  3. The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase. Nicholson WL. Appl Environ Microbiol, 2008 Nov. PMID 18820069, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Constructed was a recombinant strain BS168D by deleting the 2,3-butanediol dehydrogenase gene bdhA of the B. subtilis168, and there was almost no 2,3-butanediol production in 20 g/L of glucose media. The acetoin yield of BS168D reached 6.61 g/L, which was about 1.5 times higher than that of the control B. subtilis168 (4.47 g/L).
    Title: Effect of deletion of 2,3-butanediol dehydrogenase gene (bdhA) on acetoin production of Bacillus subtilis.
  2. Moderate-expression of YODC in the bdhA disrupted B. subtilis weakened the NADH-linked pathways to by-product pools of acetoin.
    Title: The rebalanced pathway significantly enhances acetoin production by disruption of acetoin reductase gene and moderate-expression of a new water-forming NADH oxidase in Bacillus subtilis.
  3. Bacillus subtilis ydjL (bdhA) Gene Encodes Acetoin Reductase/2,3-Butanediol Dehydrogenase
    Title: The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
acetoin reductase/2,3-butanediol dehydrogenase
NP_388505.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    677911..678951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388505.1 acetoin reductase/2,3-butanediol dehydrogenase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388505.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    cd08233
    Location:1 → 344
    butanediol_DH_like; (2R,3R)-2,3-butanediol dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O34788.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases