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sigI RNA polymerase sigma factor (heat stress responsive) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939363, updated on 1-May-2025
Gene symbol
sigI
Gene description
RNA polymerase sigma factor (heat stress responsive)
Locus tag
BSU_13450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU13450
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Sequence:
NC_000964.3 (1411892..1412647)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative integral membrane protein Neighboring gene miscRNA Neighboring gene putative manganese-related ion transporter Neighboring gene sigmaI modulating factor Neighboring gene small acid-soluble spore protein (alpha/beta-type SASP) Neighboring gene regulator of quality control

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis. Matsuoka S, et al. Genes Cells, 2022 Feb. PMID 34910349
  2. Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis. Tseng CL, et al. Arch Microbiol, 2011 Sep. PMID 21541672
  3. The heat-inducible essential response regulator WalR positively regulates transcription of sigI, mreBH and lytE in Bacillus subtilis under heat stress. Huang WZ, et al. Res Microbiol, 2013 Dec. PMID 24125693
  4. Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis. Tseng CL, et al. J Bacteriol, 2008 Mar. PMID 18156261, Free PMC Article
  5. The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis. Schirner K, et al. J Bacteriol, 2009 Mar. PMID 19114499, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis.
    Title: Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two-component system, in Bacillus subtilis.
  2. WalR appears to coordinately and positively regulate transcription of sigI, mreBH and lytE under heat stress.
    Title: The heat-inducible essential response regulator WalR positively regulates transcription of sigI, mreBH and lytE in Bacillus subtilis under heat stress.
  3. Data strongly suggest that SigI-dependent lytE expression under heat stress is important for heat survival of B. subtilis.
    Title: Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis.
  4. findings show that the mbl mutant phenotype is Mg2+ dependent, and a screen for suppressor mutations revealed that activation of the sigma I regulon overcomes the requirement for Mg2+
    Title: The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis.
  5. This further supports the notion that SigI can directly regulate mreBH and bcrC expression. and these results strongly suggest that mreBH and bcrC are new members of the SigI regulon.
    Title: Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis.
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Homology

Preferred Names
RNA polymerase sigma factor (heat stress responsive)
NP_389228.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389228.1 RNA polymerase sigma factor (heat stress responsive) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389228.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1ISG8
    Conserved Domains (1) summary
    PRK08311
    Location:14 → 251
    PRK08311; RNA polymerase sigma factor SigI
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O31654.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases