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aprE serine alkaline protease (Ca(2+)-dependent subtilisin E) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939313, updated on 6-Oct-2023

Summary

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Gene symbol
aprE
Gene description
serine alkaline protease (Ca(2+)-dependent subtilisin E)
Locus tag
BSU_10300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU10300
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Genomic context

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Sequence:
NC_000964.3 (1104423..1105568, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene putative membrane metalloprotease Neighboring gene putative N-acetyltransferase Neighboring gene putative oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin. Uehara R, et al. Biochemistry, 2013 Dec 17. PMID 24279884
  2. Bacillus subtilis SalA is a phosphorylation-dependent transcription regulator that represses scoC and activates the production of the exoprotease AprE. Derouiche A, et al. Mol Microbiol, 2015 Sep. PMID 26094643
  3. Mutational analysis of the helix-turn-helix region of Bacillus subtilis response regulator DegU, and identification of cis-acting sequences for DegU in the aprE and comK promoters. Shimane K, et al. J Biochem, 2004 Sep. PMID 15598897
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutant mimicking phosphorylation of SalA (SalA Y327E) exhibited a strong repression of scoC and consequently overproduction of AprE.
    Title: Bacillus subtilis SalA is a phosphorylation-dependent transcription regulator that represses scoC and activates the production of the exoprotease AprE.
  2. The results suggest that IS1 facilitates the formation of the Ca1 site and the complete folding of Pro-subtilisin E and thereby accelerates its autoprocessing.
    Title: Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin.
  3. DegU functions through the inverted repeat in the comK promoter and the tandem repeat in the aprE promoter
    Title: Mutational analysis of the helix-turn-helix region of Bacillus subtilis response regulator DegU, and identification of cis-acting sequences for DegU in the aprE and comK promoters.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
serine alkaline protease (Ca(2+)-dependent subtilisin E)
NP_388911.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    1104423..1105568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388911.2 serine alkaline protease (Ca(2+)-dependent subtilisin E) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388911.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1L2BPI2
    Conserved Domains (2) summary
    cd07477
    Location:131 → 359
    Peptidases_S8_Subtilisin_subset; Peptidase S8 family domain in Subtilisin proteins
    pfam05922
    Location:38 → 102
    Inhibitor_I9; Peptidase inhibitor I9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04189.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials