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lytE cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939269, updated on 6-Oct-2023

Summary

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Gene symbol
lytE
Gene description
cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)
Locus tag
BSU_09420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU09420
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Genomic context

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Sequence:
NC_000964.3 (1018998..1020002)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria Neighboring gene alkaline phosphatase A Neighboring gene transcriptional regulator CitR (LysR family) Neighboring gene citrate synthase I

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Teichoic Acid Polymers Affect Expression and Localization of dl-Endopeptidase LytE Required for Lateral Cell Wall Hydrolysis in Bacillus subtilis. Kasahara J, et al. J Bacteriol, 2016 Jun 1. PMID 27002131, Free PMC Article
  2. Deletion of the cell wall peptidoglycan hydrolase gene cwlO or lytE severely impairs transformation efficiency in Bacillus subtilis. Liu TY, et al. J Gen Appl Microbiol, 2018 Jul 23. PMID 29553055
  3. Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis. Tseng CL, et al. Arch Microbiol, 2011 Sep. PMID 21541672
  4. Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall. Hashimoto M, et al. J Bacteriol, 2012 Feb. PMID 22139507, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cell wall peptidoglycan hydrolase gene lytE is required for competence development in Bacillus subtilis.
    Title: Deletion of the cell wall peptidoglycan hydrolase gene cwlO or lytE severely impairs transformation efficiency in Bacillus subtilis.
  2. These findings suggest that teichoic acid polymers control lateral peptidoglycan hydrolysis by LytE, and bacteria drastically change their cell wall content to adapt to their environment.
    Title: Teichoic Acid Polymers Affect Expression and Localization of dl-Endopeptidase LytE Required for Lateral Cell Wall Hydrolysis in Bacillus subtilis.
  3. Endopeptidase activity of LytE or CwlO is essential for cell proliferation. These results strongly suggest that LytE and CwlO are involved in cell elongation and support the inside-to-outside model for peptidoglycan sacculus formation.
    Title: Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall.
  4. Data strongly suggest that SigI-dependent lytE expression under heat stress is important for heat survival of B. subtilis.
    Title: Genetic evidence for involvement of the alternative sigma factor SigI in controlling expression of the cell wall hydrolase gene lytE and contribution of LytE to heat survival of Bacillus subtilis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)
NP_388823.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388823.2 cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388823.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1IR62
    Conserved Domains (2) summary
    PRK06347
    Location:23 → 192
    PRK06347; 1,4-beta-N-acetylmuramoylhydrolase
    pfam00877
    Location:232 → 333
    NLPC_P60; NlpC/P60 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54421.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases