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Cers1 ceramide synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 93898, updated on 31-Jan-2019

Summary

Official Symbol
Cers1provided by MGI
Official Full Name
ceramide synthase 1provided by MGI
Primary source
MGI:MGI:2136690
See related
Ensembl:ENSMUSG00000087408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
to; Lass1; Uog-1
Summary
This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Mice lacking a functional copy of this gene exhibit impaired cerebellar development, locomotion and motor coordination. This protein is transcribed from a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]
Expression
Biased expression in frontal lobe adult (RPKM 27.2), cortex adult (RPKM 24.5) and 11 other tissues See more
Orthologs

Genomic context

See Cers1 in Genome Data Viewer
Location:
8; 8 B3.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70315775..70331588)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72839674..72855487)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene homer scaffolding protein 3 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 regulator of nonsense transcripts homolog (yeast) Neighboring gene cartilage oligomeric matrix protein Neighboring gene CREB regulated transcription coactivator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
cellular response to dithiothreitol ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to mycotoxin ISO
Inferred from Sequence Orthology
more info
 
ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ceramide synthase 1
Names
LAG1 homolog, ceramide synthase 1
LAG1 longevity assurance homolog 1
longevity assurance gene 1 protein homolog 1
longevity assurance homolog 1
protein UOG-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138647.3NP_619588.1  ceramide synthase 1

    See identical proteins and their annotated locations for NP_619588.1

    Status: REVIEWED

    Source sequence(s)
    BB665603, BC056973, M62301
    Consensus CDS
    CCDS52570.1
    UniProtKB/Swiss-Prot
    P27545
    UniProtKB/TrEMBL
    A2RT05
    Related
    ENSMUSP00000120598.1, ENSMUST00000140239.3
    Conserved Domains (1) summary
    pfam03798
    Location:98303
    TRAM_LAG1_CLN8; TLC domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    70315775..70331588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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