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blaKPC-2 carbapenemase KPC-2 [ Klebsiella pneumoniae ]

Gene ID: 9389494, discontinued on 15-Jul-2020
  • This record was discontinued.
Gene symbol
blaKPC-2
Gene description
carbapenemase KPC-2
Locus tag
pKP048_p019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Klebsiella pneumoniae (strain: KP048)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella
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Location:
plasmid: pKP048
Sequence:
NC_014312.1 (19578..20459, complement)
Genomic Sequence:
NC_014312.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The clonal spread of K. pneumoniae ST11 expressing OXA-48, KPC-2 and CTX-M-14 beta-lactamases was the cause of an outbreak of Carbapenem-resistant Klebsiella pneumoniae
    Title: Emergence and nosocomial spread of ST11 carbapenem-resistant Klebsiella pneumoniae co-producing OXA-48 and KPC-2 in a regional hospital in Taiwan.
  2. Successive emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in blaKPC-2-harboring Klebsiella pneumoniae sequence type 307 Isolates has been reported.
    Title: Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in bla(KPC-2)-Harboring Klebsiella pneumoniae Sequence Type 307 Isolates.
  3. Chromosomal integration of the Klebsiella pneumoniae carbapenemase gene, blaKPC, in Klebsiella species is elusive but not rare.
    Title: Chromosomal Integration of the Klebsiella pneumoniae Carbapenemase Gene, bla(KPC), in Klebsiella Species Is Elusive but Not Rare.
  4. Sequencing analysis of CRKP isolated strains showed that 9/98 of MBL-producing strains carried the bla VIM-1 gene and 89/98 of the isolates were positive for bla KPC-2. This finding indicates that the prevalent resistant isolates were genetically related
    Title: Emergence of Carbapenem-Resistant Klebsiella pneumoniae: Progressive Spread and Four-Year Period of Observation in a Cardiac Surgery Division.
  5. Three isoforms of Klebsiella pneumoniae bla(KPC-2) gene were used to transform Escherichia coli W4573 and its deletion mutant of an efflux pump (AcrAB) to examine the effects on beta-lactam susceptibility.
    Title: Promoter deletions of Klebsiella pneumoniae carbapenemase (KPC)-encoding genes (blaKPC -2) and efflux pump (AcrAB) on β-lactam susceptibility in KPC-producing Enterobacteriaceae.
  6. Data indicate that the bla carbapenemase (KPC) KPC-2 gene itself was not associated to increased virulence.
    Title: Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model.
  7. describes epidemiology of an outbreak of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain in a German university hospital; it was demonstrated that outbreak occurred because of the spread of a single CRKP clone harbouring both KPC-2 and VIM-1
    Title: Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.
  8. All KPC-producing isolates carried the blaKPC-2 gene.
    Title: Bloodstream infections caused by metallo-β-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes.
  9. We report two cases of KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from Cystic Fibrosis patients
    Title: KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from patients with Cystic Fibrosis.
  10. The results suggest that genetic factors affect the level of KPC production and may contribute to high-level carbapenem resistance in KPC-producing K. pneumoniae, particularly when coupled with OmpK36 porin loss.
    Title: Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.
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Preferred Names
carbapenemase KPC-2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_014312.1 Reference assembly

    Range
    19578..20459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003754012.1 carbapenemase KPC-2 [Klebsiella pneumoniae]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9F663.2