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bmr multidrug-efflux transporter [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938680, updated on 4-Feb-2024

Summary

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Gene symbol
bmr
Gene description
multidrug-efflux transporter
Locus tag
BSU_24010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU24010
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Genomic context

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Sequence:
NC_000964.3 (2494656..2495825)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene bacilliredoxin B (de-bacillithiolation) Neighboring gene putative lipid kinase BmrU Neighboring gene transcriptional regulator (MerR family) Neighboring gene branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA. Orelle C, et al. Biochemistry, 2008 Feb 26. PMID 18215075
  2. Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer. Dalmas O, et al. Biochemistry, 2005 Mar 22. PMID 15766260
  3. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  4. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
  5. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ATP-induced NBD dimerization triggers a conformational change large enough in BmrA to destabilize the rings.
    Title: Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA.
  2. The efficiency of energy transfer studied as a function of increasing concentration of BmrA, labeled with the fluorescence acceptor, argues for a dimeric association of BmrA instead of a tetrameric one.
    Title: Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
multidrug-efflux transporter
NP_390281.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390281.2 multidrug-efflux transporter [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390281.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D4FYI4
    Conserved Domains (1) summary
    cd17325
    Location:11 → 380
    MFS_MdtG_SLC18_like; bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33449.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases