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bmrR transcriptional regulator (MerR family) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938676, updated on 6-Oct-2023
Gene symbol
bmrR
Gene description
transcriptional regulator (MerR family)
Locus tag
BSU_24020
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU24020
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Sequence:
NC_000964.3 (2495898..2496734)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative lipid kinase BmrU Neighboring gene multidrug-efflux transporter Neighboring gene branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase) Neighboring gene branched-chain alpha-keto acid dehydrogenase E1 subunit

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription. Fang C, et al. Nat Commun, 2020 Dec 8. PMID 33293519, Free PMC Article
  2. Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. Kumaraswami M, et al. J Mol Biol, 2010 Apr 30. PMID 20230832, Free PMC Article
  3. Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Bachas S, et al. Proc Natl Acad Sci U S A, 2011 Jul 5. PMID 21690368, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription.
    Title: The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription.
  2. Low shape complementarity, suboptimal packing, and efficient burial of a diverse set of ligands is facilitated by an aromatic docking platform formed by a set of conformationally fixed aromatic residues.
    Title: Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR.
  3. the crystal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E) was reported.
    Title: Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.
Submit: New GeneRIF Correction

Homology

Preferred Names
transcriptional regulator (MerR family)
NP_390282.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390282.2 transcriptional regulator (MerR family) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390282.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1JGE8
    Conserved Domains (2) summary
    cd01107
    Location:6 → 112
    HTH_BmrR; Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator
    COG4978
    Location:121 → 278
    BltR2; Bacterial effector-binding domain [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39075.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases