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spo0A response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938655, updated on 6-Oct-2023

Summary

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Gene symbol
spo0A
Gene description
response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT
Locus tag
BSU_24220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU24220
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Genomic context

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Sequence:
NC_000964.3 (2518023..2518826, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene putative NADH-dependent flavin oxidoreductase Neighboring gene regulatory membrane-associated serine protease Neighboring gene factor for double strand breaks DNA repair and genetic recombination

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. Russell JR, et al. EMBO J, 2017 Oct 2. PMID 28838935, Free PMC Article
  2. Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis. Boonstra M, et al. Mol Microbiol, 2013 Feb. PMID 23301687
  3. Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms. Chastanet A, et al. J Bacteriol, 2011 Nov. PMID 21949067, Free PMC Article
  4. Fluctuations in spo0A transcription control rare developmental transitions in Bacillus subtilis. Mirouze N, et al. PLoS Genet, 2011 Apr. PMID 21552330, Free PMC Article
  5. Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis. Bidnenko V, et al. PLoS Genet, 2017 Jul. PMID 28723971, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MecA inhibits the transcription of several Spo0A-P activated genes, but fails to de-repress several Spo0A-P repressed promoters.
    Title: ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation.
  2. Cells exhibit a constant probability of attaining a high threshold level of Spo0A~P due to fluctuations in the flux of phosphoryl groups through the phosphorelay.
    Title: Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis.
  3. our findings indicate that distinct Rho-controlled transcripts are functional and constitute a previously unknown built-in module for the control of cell differentiation in B. subtilis. In a broader context, our results highlight the recruitment of the termination factor Rho, for which the conserved biological role is probably to repress pervasive transcription, in highly integrated, bacterium-specific, regulatory network
    Title: Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis.
  4. The pulsed behavior of Spo0A~P allows the introduction of a time delay between the activations of KinA and Spo0A~P. (Review)
    Title: Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay.
  5. Spo0A binds to the upstream region of epr promoter and in turn occludes the binding site of one of the co-repressor, SinR.
    Title: Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis.
  6. Spo0A regulates chromosome copy number during sporulation by binding to the origin of replication.
    Title: Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis.
  7. Spo0A synthes is governed by a promoter switching mechanism during different growth stages.
    Title: Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms.
  8. Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med.
    Title: Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis.
  9. The increase in spo0A transcription during early growth phase results in the synthesis of phosphorylated Spo0A.
    Title: Fluctuations in spo0A transcription control rare developmental transitions in Bacillus subtilis.
  10. kinC and kinD are responsible for expression of spo0A during logarithmical growth that are not sufficient to activate sporulation, but sufficient for suppression of the lytic cycle of phi 29.
    Title: kinC/D-mediated heterogeneous expression of spo0A during logarithmical growth in Bacillus subtilis is responsible for partial suppression of phi 29 development.
Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Homology

General protein information

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Preferred Names
response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT
NP_390302.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    2518023..2518826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390302.1 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390302.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1L772
    Conserved Domains (1) summary
    TIGR02875
    Location:2 → 267
    spore_0_A; sporulation transcription factor Spo0A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06534.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials