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clpP ATP-dependent Clp protease proteolytic subunit; Maxwell's demon [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938625, updated on 6-Oct-2023

Summary

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Gene symbol
clpP
Gene description
ATP-dependent Clp protease proteolytic subunit; Maxwell's demon
Locus tag
BSU_34540
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU34540
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Genomic context

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Sequence:
NC_000964.3 (3546234..3546827)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene spore coat lipolytic enzyme Neighboring gene tRNA-Arg Neighboring gene bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase Neighboring gene oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase) Neighboring gene maltose phosphorylase Neighboring gene putative component of maltodextrin transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee BG, et al. Nat Struct Mol Biol, 2010 Apr. PMID 20305655
  2. Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP. Silber N, et al. mBio, 2020 Jun 30. PMID 32605984, Free PMC Article
  3. Stability of Proteins Out of Service: the GapB Case of Bacillus subtilis. Gerth U, et al. J Bacteriol, 2017 Oct 15. PMID 28760849, Free PMC Article
  4. Molecular determinants of MecA as a degradation tag for the ClpCP protease. Mei Z, et al. J Biol Chem, 2009 Dec 4. PMID 19767395, Free PMC Article
  5. Autoregulation of the Bacillus subtilis response regulator gene degU is coupled with the proteolysis of DegU-P by ClpCP. Ogura M, et al. Mol Microbiol, 2010 Mar. PMID 20070525

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP.
    Title: Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP.
  2. Comparative in vivo pulse-chase labeling and immunoprecipitation experiments of the wild-type strain and isogenic mutants identified the ATP-dependent ClpCP protease as the enzyme responsible for the degradation of GapB.
    Title: Stability of Proteins Out of Service: the GapB Case of Bacillus subtilis.
  3. Western blot analysis of DegU in disruption mutants of genes encoding various ATP-dependent proteases strongly suggested that ClpCP degrades DegU.
    Title: Autoregulation of the Bacillus subtilis response regulator gene degU is coupled with the proteolysis of DegU-P by ClpCP.
  4. present the structures of Bacillus subtilis ClpP alone and in complex with ADEP1 and ADEP2. The structures show the closed-to-open-gate transition of the ClpP N-terminal segments
    Title: Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism.
  5. ClpCP protease undergoes dynamic cycles of assembly and disassembly, which are triggered by association with MecA and the degradation of MecA, respectively
    Title: Molecular determinants of MecA as a degradation tag for the ClpCP protease.
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General gene information

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Homology

General protein information

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Preferred Names
ATP-dependent Clp protease proteolytic subunit; Maxwell's demon
NP_391334.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391334.1 ATP-dependent Clp protease proteolytic subunit; Maxwell's demon [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391334.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A166U5Z8
    Conserved Domains (1) summary
    PRK00277
    Location:1 → 196
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80244.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials