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mntR transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938554, updated on 6-Jun-2024
Gene symbol
mntR
Gene description
transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)
Locus tag
BSU_24520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU24520
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Sequence:
NC_000964.3 (2543440..2543868, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene putative lipase / acyl esterase Neighboring gene protein octanoyltransferase Neighboring gene putative sulfur transferase

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Metal binding studies and EPR spectroscopy of the manganese transport regulator MntR. Golynskiy MV, et al. Biochemistry, 2006 Dec 26. PMID 17176058, Free PMC Article
  2. The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. DeWitt MA, et al. J Mol Biol, 2007 Feb 2. PMID 17118401, Free PMC Article
  3. Metal-induced structural organization and stabilization of the metalloregulatory protein MntR. Golynskiy MV, et al. Biochemistry, 2005 Mar 8. PMID 15736948
  4. Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis. Helmann JD. J Biol Chem, 2014 Oct 10. PMID 25160631, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Iron and manganese homeostasis in Bacillus subtilis involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. (Review)
    Title: Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
  2. MntR belongs to a class of metalloregulatory proteins that possess a weak affinity for its cognate metal ion, while still eliciting tight DNA binding upon complete metal loading.
    Title: Metal binding studies and EPR spectroscopy of the manganese transport regulator MntR.
  3. Electron Spin Resonance Spectroscopy spectra of the spin-labeled mutant indicate that tertiary structure is conserved in the presence or absence of bound metals, though slightly greater flexibility is present in inactive forms of MntR.
    Title: The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.
  4. Experiments indicate that MntR undergoes a significant conformational change upon metal binding that results in stabilization of the protein structure.
    Title: Metal-induced structural organization and stabilization of the metalloregulatory protein MntR.
Submit: New GeneRIF Correction

Homology

Preferred Names
transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)
NP_390332.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    2543440..2543868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390332.2 transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390332.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D4FYP0
    Conserved Domains (1) summary
    PRK03902
    Location:1 → 142
    PRK03902; transcriptional regulator MntR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54512.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases