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clpC class III stress response-related ATPase, AAA+ superfamily [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938481, updated on 6-Oct-2023

Summary

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Gene symbol
clpC
Gene description
class III stress response-related ATPase, AAA+ superfamily
Locus tag
BSU_00860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU00860
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Genomic context

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Sequence:
NC_000964.3 (103572..106004)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene transcriptional regulator of class III stress genes Neighboring gene activator of protein kinase McsB Neighboring gene protein arginine kinase Neighboring gene DNA repair protein; 6-O-methylguanine-DNA methyltransferase Neighboring gene diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions. Kojetin DJ, et al. J Mol Biol, 2009 Apr 3. PMID 19361434, Free PMC Article
  2. Activity control of the ClpC adaptor McsB in Bacillus subtilis. Elsholz AK, et al. J Bacteriol, 2011 Aug. PMID 21622759, Free PMC Article
  3. ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation. Tanner AW, et al. Mol Microbiol, 2018 Apr. PMID 29446505, Free PMC Article
  4. Stability of Proteins Out of Service: the GapB Case of Bacillus subtilis. Gerth U, et al. J Bacteriol, 2017 Oct 15. PMID 28760849, Free PMC Article
  5. Molecular determinants of MecA as a degradation tag for the ClpCP protease. Mei Z, et al. J Biol Chem, 2009 Dec 4. PMID 19767395, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A complex of MecA and ClpC likely binds to Spo0A-P on its target promoters, preventing the activation of transcription.
    Title: ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation.
  2. Comparative in vivo pulse-chase labeling and immunoprecipitation experiments of the wild-type strain and isogenic mutants identified the ATP-dependent ClpCP protease as the enzyme responsible for the degradation of GapB.
    Title: Stability of Proteins Out of Service: the GapB Case of Bacillus subtilis.
  3. Thus, degU is induced through activation of autoregulation by a decrease in ClpCP-dependent proteolysis of DegU-P.
    Title: The Bacillus subtilis response regulator gene degU is positively regulated by CcpA and by catabolite-repressed synthesis of ClpC.
  4. McsB kinase activity is inhibited by ClpC.
    Title: Activity control of the ClpC adaptor McsB in Bacillus subtilis.
  5. Western blot analysis of DegU in disruption mutants of genes encoding various ATP-dependent proteases strongly suggested that ClpCP degrades DegU.
    Title: Autoregulation of the Bacillus subtilis response regulator gene degU is coupled with the proteolysis of DegU-P by ClpCP.
  6. ClpCP protease undergoes dynamic cycles of assembly and disassembly, which are triggered by association with MecA and the degradation of MecA, respectively
    Title: Molecular determinants of MecA as a degradation tag for the ClpCP protease.
  7. Results suggest that the electrostatic surface characteristics of HSP100/Clp N-domains may play a role in adaptor protein and substrate interaction specificity, and perhaps contribute to the unique adaptor protein requirement of ClpC.
    Title: Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions.
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General gene information

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Homology

General protein information

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Preferred Names
class III stress response-related ATPase, AAA+ superfamily
NP_387967.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_387967.1 class III stress response-related ATPase, AAA+ superfamily [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_387967.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KVK5
    Conserved Domains (1) summary
    CHL00095
    Location:2 → 803
    clpC; Clp protease ATP binding subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37571.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials