crh catabolite repression HPr-like protein [Bacillus subtilis subsp. subtilis str. 168] - Gene

Summary

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Gene symbol: crh
Gene description: catabolite repression HPr-like protein
Locus tag: BSU_34740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag: BSU34740
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Genomic context

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Sequence:: NC_000964.3 (3569292..3569549, complement)

NC_000964.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_000964.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro cross-linking studies revealed that Crh interacts with the N-terminal helices of MgsA and that the Crh-MgsA binding inactivates MgsA by distorting and thereby blocking its active site.
Title: Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.
During exponential growth, ~80% of the Crh molecules were phosphorylated when cells utilized a preferred carbon source.
Title: Carbon source control of the phosphorylation state of the Bacillus subtilis carbon-flux regulator Crh in vivo.
The authors show here that exclusively the non-phosphorylated form of Crh interacts with MgsA in vivo and inhibits MgsA activity in vitro.
Title: Crh, the paralogue of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in Bacillus subtilis.
Data suggest specific roles for fructose-1,6-bisphosphate and glucose-6-phosphate in enhancing HPrSerP-, but not CrhP-mediated carbon catabolite regulation through CcpA.
Title: Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis.
the interface between catabolite control protein A (CcpA) and helix alpha 2 of the second contact region (contact region II) of Crh-Ser46-P is necessary and sufficient to throw the allosteric switch to activate cre binding by CcpA.
Title: Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
X-ray structure of a domain-swapped dimer of Ser46-phosphorylated Crh from Bacillus subtilis
Title: X-ray structure of a domain-swapped dimer of Ser46-phosphorylated Crh from Bacillus subtilis.

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: catabolite repression HPr-like protein

NP_391354.1

Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000964.3 Reference assembly

Range

3569292..3569549 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_391354.1 catabolite repression HPr-like protein [Bacillus subtilis subsp. subtilis str. 168]

See identical proteins and their annotated locations for NP_391354.1

Status: PROVISIONAL

Conserved Domains (1) summary

PRK13782
Location:1 → 82

PRK13782; HPr family phosphocarrier protein