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TSIX TSIX transcript, XIST antisense RNA [ Homo sapiens (human) ]

Gene ID: 9383, updated on 7-Jul-2022

Summary

Official Symbol
TSIXprovided by HGNC
Official Full Name
TSIX transcript, XIST antisense RNAprovided by HGNC
Primary source
HGNC:HGNC:12377
See related
Ensembl:ENSG00000270641 MIM:300181; AllianceGenome:HGNC:12377
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XISTAS; XIST-AS; XIST-AS1; LINC00013; NCRNA00013
Summary
In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]
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Genomic context

See TSIX in Genome Data Viewer
Location:
Xq13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (73792205..73829231)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (72225527..72262546)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (73012040..73049066)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cysteine rich hydrophobic domain 1 Neighboring gene selenophosphate synthetase 1 pseudogene 4 Neighboring gene X inactive specific transcript Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 3 Neighboring gene JPX transcript, XIST activator Neighboring gene ribosomal protein SA pseudogene 14 Neighboring gene FTX transcript, XIST regulator

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • TSIX transcript, XIST antisense RNA (non-protein coding)
  • X (inactive)-specific transcript, antisense (non-protein coding)
  • XIST antisense RNA (non-protein coding)
  • long intergenic non-protein coding RNA 13
  • x-inactivation-specific transcript-antisense

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin-protein adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in inactivation of X chromosome by heterochromatin formation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of dosage compensation complex TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003255.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL353804, AL356513, AL683895
    Related
    ENST00000604411.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    73792205..73829231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    72225527..72262546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)