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gabR transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938271, updated on 1-May-2025
Gene symbol
gabR
Gene description
transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)
Locus tag
BSU_03890
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU03890
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Sequence:
NC_000964.3 (440025..441464, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative AI-2 degrading enzyme Neighboring gene putative transcriptional regulator (ArsR family) Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene succinate-semialdehyde dehydrogenase

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. (S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR. Catlin DS, et al. Protein Sci, 2020 Aug. PMID 32557944, Free PMC Article
  2. Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by γ-aminobutyric acid binding, inducing transcriptional activation. Park SA, et al. Biochem Biophys Res Commun, 2017 May 27. PMID 28412355
  3. Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation. Nardella C, et al. FEBS J, 2020 Nov. PMID 32147931
  4. Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site. Al-Zyoud WA, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26681693, Free PMC Article
  5. Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. Okuda K, et al. J Biochem, 2015 Sep. PMID 25911692

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation.
    Title: Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation.
  2. (S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR.
    Title: (S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR.
  3. One subunit is a closed-form containing the PLP-GABA adduct, and the other subunit is a PLP-bound open-form. Our structural studies provide a detailed mechanism indicating that the open-to-closed transition by the binding of GABA induces the conformational rearrangement of BsGabR-CTD, which may trigger the activation of transcription.
    Title: Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by γ-aminobutyric acid binding, inducing transcriptional activation.
  4. Data show that DNA undergoes a conformational change to bend around transcription factor GabR during binding.
    Title: Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site.
  5. These results suggested that each domain of GabR could be an independent folding unit. The C-terminal domain provides the N-terminal domain with DNA-binding ability via dimerization.
    Title: Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator.
  6. study examined the mechanism underlying GabR-mediated gabTD transcription, focusing on the function of the aminotransferase domain.
    Title: Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator.
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Homology

Preferred Names
transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)
NP_388271.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    440025..441464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388271.1 transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388271.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P94426
    Conserved Domains (1) summary
    COG1167
    Location:15 → 474
    ARO8; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P94426.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases