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rsbRA component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938176, updated on 6-Oct-2023

Summary

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Gene symbol
rsbRA
Gene description
component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress
Locus tag
BSU_04670
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU04670
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Genomic context

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Sequence:
NC_000964.3 (519408..520232)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene antitoxin EndoAI Neighboring gene endoribonuclease toxin Neighboring gene antagonist of RsbT Neighboring gene switch protein/serine-threonine kinase; controls the activity of the anxiosome (stressosome)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA. Choi S, et al. Biochemistry, 2020 Dec 22. PMID 33287544
  2. Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. Cabeen MT, et al. PLoS Genet, 2017 Jul. PMID 28727759, Free PMC Article
  3. Red light activates the sigmaB-mediated general stress response of Bacillus subtilis via the energy branch of the upstream signaling cascade. Avila-Pérez M, et al. J Bacteriol, 2010 Feb. PMID 19948797, Free PMC Article
  4. Differentiation of function among the RsbR paralogs in the general stress response of Bacillus subtilis with regard to light perception. van der Steen JB, et al. J Bacteriol, 2012 Apr. PMID 22287516, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA.
    Title: Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA.
  2. mutant cells producing only one of the four paralogous RsbR stressosome proteins showed striking and previously unseen differences. Whereas RsbRA-only cells mimicked the wild type, RsbRC-only cells displayed a slower but sustained overall response composed of repeated activation events in single cells.
    Title: Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis.
  3. RsbRB and RsbRA function antagonistically in the YtvA-dependent light activation of the stress response.
    Title: Differentiation of function among the RsbR paralogs in the general stress response of Bacillus subtilis with regard to light perception.
  4. sigma(B) can be activated by red light via the energy branch of its upstream signaling cascade.
    Title: Red light activates the sigmaB-mediated general stress response of Bacillus subtilis via the energy branch of the upstream signaling cascade.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress
NP_388348.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388348.1 component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388348.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1L4Y1
    Conserved Domains (2) summary
    cd07041
    Location:150 → 258
    STAS_RsbR_RsbS_like; Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation
    cd19413
    Location:7 → 136
    RsbR_N-like; globin-like domain of positive regulator of sigma-B activity (RsbRA)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42409.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases