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smc chromosome condensation and segregation SMC ATPase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 938085, updated on 6-Oct-2023

Summary

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Gene symbol
smc
Gene description
chromosome condensation and segregation SMC ATPase
Locus tag
BSU_15940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU15940
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Genomic context

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Sequence:
NC_000964.3 (1666560..1670120)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene acyl carrier protein Neighboring gene ribonuclease III Neighboring gene signal recognition particle (docking protein) Neighboring gene conserved exported protein of unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization. Diebold-Durand ML, et al. Mol Cell, 2017 Jul 20. PMID 28689660, Free PMC Article
  2. The SMC condensin complex is required for origin segregation in Bacillus subtilis. Wang X, et al. Curr Biol, 2014 Feb 3. PMID 24440393, Free PMC Article
  3. SMC condensation centers in Bacillus subtilis are dynamic structures. Kleine Borgmann LA, et al. J Bacteriol, 2013 May. PMID 23475963, Free PMC Article
  4. Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis. Tadesse S, et al. Microbiology (Reading), 2005 Nov. PMID 16272394
  5. Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA. Minnen A, et al. Cell Rep, 2016 Mar 1. PMID 26904953, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sandwiching of ATP molecules between Smc heads requires them to substantially tilt and translate relative to each other, thereby opening up the Smc arms. This mechanochemical gating reaction regulates chromosome targeting and propose a mechanism for DNA translocation based on the merging of DNA loops upon closure of Smc arms.
    Title: Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.
  2. Targeting of Smc/ScpAB to ParB/parS loading sites is strictly dependent on engagement of Smc head domains and relies on an open organization of the Smc coiled coils.
    Title: Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA.
  3. we show that rapid inactivation of SMC or its partner protein ScpB during fast growth leads to a failure to resolve newly replicated origins and a complete block to chromosome segregation.
    Title: The SMC condensin complex is required for origin segregation in Bacillus subtilis.
  4. A mutation in SMC that affects ATPase activity and results in exaggerated DNA binding causes a strong segregation defect and affects the localization of the SMC complex, which localizes to many more sites in the cell than under normal conditions
    Title: SMC condensation centers in Bacillus subtilis are dynamic structures.
  5. An Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes.
    Title: An asymmetric SMC-kleisin bridge in prokaryotic condensin.
  6. has a dual function, in chromosome supercoiling and in active segregation
    Title: Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis.
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General gene information

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Homology

General protein information

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Preferred Names
chromosome condensation and segregation SMC ATPase
NP_389476.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389476.2 chromosome condensation and segregation SMC ATPase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389476.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KV42
    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 1178
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51834.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials