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rnpA protein component of ribonuclease P (RNase P) (substrate specificity) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937930, updated on 12-Feb-2021
Gene symbol
rnpA
Gene description
protein component of ribonuclease P (RNase P) (substrate specificity)
Locus tag
BSU_41050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU41050
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Sequence:
NC_000964.3 (4214753..4215103, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene tRNA modification GTPase and tRNA-U34 5-formylation enzyme Neighboring gene SpoIIIJ-associated RNA/ssDNA-binding protein Neighboring gene Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family) Neighboring gene ribosomal protein L34

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion. Baird NJ, et al. J Mol Biol, 2010 Apr 16. PMID 20188108, Free PMC Article
  2. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Koutmou KS, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133747, Free PMC Article
  3. Function of heterologous and truncated RNase P proteins in Bacillus subtilis. Gösringer M, et al. Mol Microbiol, 2007 Nov. PMID 17919279
  4. Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression. Gössringer M, et al. J Bacteriol, 2006 Oct. PMID 16980484, Free PMC Article
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA folding intermediates adopt extended conformations due to short-range, nonnative interactions rather than generic electrostatic repulsion of helical domains
    Title: Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion.
  2. Studies present a unique picture of how metals coordinate to the putative RNase P active site in solution, and shed light on the environment of an essential metal ion in RNase P.
    Title: NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P.
  3. Data support that the notion that archaeal/eukaryal RNase P proteins are evolutionary unrelated to the bacterial RnpA protein.
    Title: Function of heterologous and truncated RNase P proteins in Bacillus subtilis.
  4. This is the first RNase P protein knockdown strain, providing the first direct proof that the rnpA gene is essential in B. subtilis and, by inference, in other bacteria.
    Title: Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression.
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Homology

Preferred Names
protein component of ribonuclease P (RNase P) (substrate specificity)
NP_391985.1
  • Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    4214753..4215103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391985.1 protein component of ribonuclease P (RNase P) (substrate specificity) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391985.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK00499
    Location:3 → 105
    rnpA; ribonuclease P; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25814.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases