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NRXN2 neurexin 2 [ Homo sapiens (human) ]

Gene ID: 9379, updated on 26-Oct-2020

Summary

Official Symbol
NRXN2provided by HGNC
Official Full Name
neurexin 2provided by HGNC
Primary source
HGNC:HGNC:8009
See related
Ensembl:ENSG00000110076 MIM:600566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Expression
Biased expression in brain (RPKM 25.4), testis (RPKM 3.9) and 2 other tissues See more
Orthologs

Genomic context

See NRXN2 in Genome Data Viewer
Location:
11q13.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64606174..64723197, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64373646..64490660, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 11 Neighboring gene solute carrier family 22 member 12 Neighboring gene NRXN2 antisense RNA 1 Neighboring gene RAS guanyl releasing protein 2 Neighboring gene glycogen phosphorylase, muscle associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40892, KIAA0921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neuroligin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
gephyrin clustering involved in postsynaptic density assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroligin clustering involved in postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density protein 95 clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
vocal learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurexin-2-beta
Names
neurexin II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047107.1 RefSeqGene

    Range
    4992..122015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001376262.1NP_001363191.1  neurexin-2-beta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001092, AP001462
    Conserved Domains (5) summary
    smart00282
    Location:516666
    LamG; Laminin G domain
    cd00054
    Location:694727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14431482
    Syndecan; Syndecan domain
    pfam02210
    Location:9461071
    Laminin_G_2; Laminin G domain
  2. NM_001376263.1NP_001363192.1  neurexin-2-beta isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001092, AP001462
    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14361475
    Syndecan; Syndecan domain
    pfam02210
    Location:9391064
    Laminin_G_2; Laminin G domain
  3. NM_001376265.1NP_001363194.1  neurexin-2-beta isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001092, AP001462
    Conserved Domains (5) summary
    smart00282
    Location:501651
    LamG; Laminin G domain
    cd00054
    Location:679712
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14281467
    Syndecan; Syndecan domain
    pfam02210
    Location:9311056
    Laminin_G_2; Laminin G domain
  4. NM_001376266.1NP_001363195.1  neurexin-2-beta isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001092, AP001462
    Conserved Domains (5) summary
    smart00282
    Location:508658
    LamG; Laminin G domain
    cd00054
    Location:686719
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14351474
    Syndecan; Syndecan domain
    pfam02210
    Location:9381063
    Laminin_G_2; Laminin G domain
  5. NM_001376267.1NP_001363196.1  neurexin-2-beta isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001092, AP001462
    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14061445
    Syndecan; Syndecan domain
    pfam02210
    Location:9391064
    Laminin_G_2; Laminin G domain
  6. NM_015080.4NP_055895.1  neurexin-2-beta isoform alpha-1 precursor

    See identical proteins and their annotated locations for NP_055895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha-1) encodes the longest isoform (alpha-1).
    Source sequence(s)
    AP001092, AP001462
    Consensus CDS
    CCDS8077.1
    UniProtKB/Swiss-Prot
    Q9P2S2
    Related
    ENSP00000265459.5, ENST00000265459.11
    Conserved Domains (5) summary
    smart00282
    Location:516666
    LamG; Laminin G domain
    cd00054
    Location:694727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16371676
    Syndecan; Syndecan domain
    pfam02210
    Location:9461074
    Laminin_G_2; Laminin G domain
  7. NM_138732.3NP_620060.1  neurexin-2-beta isoform alpha-2 precursor

    See identical proteins and their annotated locations for NP_620060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha-2) lacks 3 exons and a portion from a fourth exon in the coding region, as compared to variant alpha-2. It encodes isoform alpha-2 which is missing 4 internal aa fragments but has identical N- and C-termini to isoform alpha-1.
    Source sequence(s)
    AB023138, AP001092, AP001462
    Consensus CDS
    CCDS31597.1
    UniProtKB/Swiss-Prot
    Q9P2S2
    Related
    ENSP00000366782.3, ENST00000377559.7
    Conserved Domains (5) summary
    smart00282
    Location:485635
    LamG; Laminin G domain
    cd00054
    Location:663696
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:15671606
    Syndecan; Syndecan domain
    pfam02210
    Location:9061034
    Laminin_G_2; Laminin G domain
  8. NM_138734.3NP_620063.1  neurexin-2-beta isoform beta precursor

    See identical proteins and their annotated locations for NP_620063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) lacks most 5' exons and has an alternate exon at the 5' end, as compared to variant alpha-1. It encodes isoform beta which has a much shorter and different N-terminus than isoform alpha-1 (PMID: 12036300 and PMID: 11944992).
    Source sequence(s)
    AP001092
    Consensus CDS
    CCDS8078.1
    UniProtKB/Swiss-Prot
    P58401
    Related
    ENSP00000301894.2, ENST00000301894.6
    Conserved Domains (3) summary
    PHA03247
    Location:387586
    PHA03247; large tegument protein UL36; Provisional
    cd00110
    Location:92270
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:591630
    Syndecan; Syndecan domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64606174..64723197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018569.1XP_016874058.1  neurexin-2-beta isoform X14

  2. XM_017018564.1XP_016874053.1  neurexin-2-beta isoform X6

  3. XM_017018563.1XP_016874052.1  neurexin-2-beta isoform X5

  4. XM_024448776.1XP_024304544.1  neurexin-2-beta isoform X30

    Conserved Domains (5) summary
    smart00282
    Location:477627
    LamG; Laminin G domain
    cd00054
    Location:655688
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:13651404
    Syndecan; Syndecan domain
    pfam02210
    Location:8981026
    Laminin_G_2; Laminin G domain
  5. XM_024448772.1XP_024304540.1  neurexin-2-beta isoform X15

    Conserved Domains (6) summary
    smart00282
    Location:477627
    LamG; Laminin G domain
    cd00054
    Location:655688
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:15891628
    Syndecan; Syndecan domain
    pfam02210
    Location:8981026
    Laminin_G_2; Laminin G domain
    cl26464
    Location:13851584
    Atrophin-1; Atrophin-1 family
  6. XM_024448775.1XP_024304543.1  neurexin-2-beta isoform X29

    Conserved Domains (5) summary
    smart00282
    Location:485635
    LamG; Laminin G domain
    cd00054
    Location:663696
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14121451
    Syndecan; Syndecan domain
    pfam02210
    Location:9151043
    Laminin_G_2; Laminin G domain
  7. XM_024448771.1XP_024304539.1  neurexin-2-beta isoform X13

    Conserved Domains (6) summary
    smart00282
    Location:485635
    LamG; Laminin G domain
    cd00054
    Location:663696
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16061645
    Syndecan; Syndecan domain
    pfam02210
    Location:9151043
    Laminin_G_2; Laminin G domain
    cl26464
    Location:14021601
    Atrophin-1; Atrophin-1 family
  8. XM_024448770.1XP_024304538.1  neurexin-2-beta isoform X11

    Conserved Domains (6) summary
    smart00282
    Location:485635
    LamG; Laminin G domain
    cd00054
    Location:663696
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16091648
    Syndecan; Syndecan domain
    pfam02210
    Location:9181046
    Laminin_G_2; Laminin G domain
    cl26464
    Location:14051604
    Atrophin-1; Atrophin-1 family
  9. XM_017018566.1XP_016874055.1  neurexin-2-beta isoform X9

  10. XM_011545371.1XP_011543673.1  neurexin-2-beta isoform X2

    Conserved Domains (5) summary
    smart00282
    Location:515665
    LamG; Laminin G domain
    cd00054
    Location:693726
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16391678
    Syndecan; Syndecan domain
    pfam02210
    Location:9481076
    Laminin_G_2; Laminin G domain
  11. XM_011545375.1XP_011543677.1  neurexin-2-beta isoform X8

    Conserved Domains (5) summary
    smart00282
    Location:501651
    LamG; Laminin G domain
    cd00054
    Location:679712
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16251664
    Syndecan; Syndecan domain
    pfam02210
    Location:9341062
    Laminin_G_2; Laminin G domain
  12. XM_005274400.3XP_005274457.1  neurexin-2-beta isoform X4

    See identical proteins and their annotated locations for XP_005274457.1

    UniProtKB/TrEMBL
    G5E9G7
    Related
    ENSP00000386416.1, ENST00000409571.5
    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16301669
    Syndecan; Syndecan domain
    pfam02210
    Location:9391067
    Laminin_G_2; Laminin G domain
  13. XM_011545373.1XP_011543675.1  neurexin-2-beta isoform X3

    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16331672
    Syndecan; Syndecan domain
    pfam02210
    Location:9421070
    Laminin_G_2; Laminin G domain
  14. XM_017018573.1XP_016874062.1  neurexin-2-beta isoform X22

  15. XM_017018565.1XP_016874054.1  neurexin-2-beta isoform X7

  16. XM_017018578.1XP_016874067.1  neurexin-2-beta isoform X31

  17. XM_017018568.1XP_016874057.1  neurexin-2-beta isoform X12

  18. XM_024448773.1XP_024304541.1  neurexin-2-beta isoform X20

    Conserved Domains (5) summary
    smart00282
    Location:516666
    LamG; Laminin G domain
    cd00054
    Location:694727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14161455
    Syndecan; Syndecan domain
    pfam02210
    Location:9491077
    Laminin_G_2; Laminin G domain
  19. XM_017018567.1XP_016874056.1  neurexin-2-beta isoform X10

  20. XM_017018570.1XP_016874059.1  neurexin-2-beta isoform X16

  21. XM_011545370.1XP_011543672.1  neurexin-2-beta isoform X1

    Conserved Domains (5) summary
    smart00282
    Location:516666
    LamG; Laminin G domain
    cd00054
    Location:694727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16401679
    Syndecan; Syndecan domain
    pfam02210
    Location:9491077
    Laminin_G_2; Laminin G domain
  22. XM_017018575.1XP_016874064.1  neurexin-2-beta isoform X24

  23. XM_017018574.1XP_016874063.1  neurexin-2-beta isoform X23

  24. XM_017018572.1XP_016874061.1  neurexin-2-beta isoform X21

  25. XM_017018576.1XP_016874065.1  neurexin-2-beta isoform X25

    Conserved Domains (4) summary
    smart00282
    Location:97247
    LamG; Laminin G domain
    cd00054
    Location:275308
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01034
    Location:12211260
    Syndecan; Syndecan domain
    pfam02210
    Location:530658
    Laminin_G_2; Laminin G domain
  26. XM_017018577.1XP_016874066.1  neurexin-2-beta isoform X27

  27. XM_011545385.1XP_011543687.1  neurexin-2-beta isoform X26

    Conserved Domains (2) summary
    pfam01034
    Location:902941
    Syndecan; Syndecan domain
    pfam02210
    Location:211339
    Laminin_G_2; Laminin G domain
  28. XM_024448774.1XP_024304542.1  neurexin-2-beta isoform X28

    Conserved Domains (3) summary
    PHA03247
    Location:278477
    PHA03247; large tegument protein UL36; Provisional
    pfam01034
    Location:482521
    Syndecan; Syndecan domain
    pfam02210
    Location:44160
    Laminin_G_2; Laminin G domain

RNA

  1. XR_001748043.2 RNA Sequence

  2. XR_001748044.1 RNA Sequence

  3. XR_001748042.1 RNA Sequence

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