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purA adenylosuccinate synthetase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937805, updated on 12-Feb-2021

Summary

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Gene symbol
purA
Gene description
adenylosuccinate synthetase
Locus tag
BSU_40420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU40420
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Genomic context

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Sequence:
NC_000964.3 (4155433..4156725, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene tRNA-Lys Neighboring gene hypothetical protein Neighboring gene replicative DNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Qian J, et al. Biotechnol Lett, 2006 Jun. PMID 16786280
  2. Mutational analysis of the Bacillus subtilis purA operator site. Rappu P, et al. Curr Microbiol, 2005 Nov. PMID 16163456
  3. Increased fermentative adenosine production by gene-targeted Bacillus subtilis mutation. Li B, et al. J Biotechnol, 2019 Jun 10. PMID 30974118
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. As the synthesis of succinyladenosine monophosphate (sAMP) from IMP catalysed by adenylosuccinate synthetase (encoded by purA gene) is the rate-limiting step in adenosine synthesis, the up-regulated transcription level of purA was the potential underlying mechanism for the increased adenosine production.
    Title: Increased fermentative adenosine production by gene-targeted Bacillus subtilis mutation.
  2. data presented here indicate that purA PurBox has a similar role as pur operon PurBox in PurR binding
    Title: Mutational analysis of the Bacillus subtilis purA operator site.
  3. A single nucleotide deletion at position 55 in purA gene was found in a high inosine-producing strain of B. subtilis and in a high guanosine-producing strain, which correlates with the absence of adenylosuccinate synthetase activity in these strains
    Title: Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
adenylosuccinate synthetase
NP_391922.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    4155433..4156725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391922.1 adenylosuccinate synthetase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391922.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P29726
    Conserved Domains (1) summary
    PRK01117
    Location:1 → 429
    PRK01117; adenylosuccinate synthetase; Provisional
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials