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NRXN1 neurexin 1 [ Homo sapiens (human) ]

Gene ID: 9378, updated on 2-Oct-2018

Summary

Official Symbol
NRXN1provided by HGNC
Official Full Name
neurexin 1provided by HGNC
Primary source
HGNC:HGNC:8008
See related
Ensembl:ENSG00000179915 MIM:600565; Vega:OTTHUMG00000129263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTHSL2; SCZD17; Hs.22998
Summary
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
Expression
Biased expression in brain (RPKM 12.7) and testis (RPKM 0.6) See more
Orthologs

Genomic context

See NRXN1 in Genome Data Viewer
Location:
2p16.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (49918505..51032536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (50145643..51259674, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374595 Neighboring gene ribosomal protein L7 pseudogene 13 Neighboring gene VISTA enhancer hs1348 Neighboring gene uncharacterized LOC101927089 Neighboring gene MT-CO1 pseudogene 42 Neighboring gene microRNA 8485 Neighboring gene uncharacterized LOC730100 Neighboring gene uncharacterized LOC105377627 Neighboring gene lysine rich nucleolar protein 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Pitt-Hopkins-like syndrome 2
MedGen: C3280479 OMIM: 614325 GeneReviews: Not available
Compare labs
Schizophrenia 17
MedGen: C3280524 OMIM: 614332 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-05-17)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-05-17)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
NHGRI GWA Catalog
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Joint influence of small-effect genetic variants on human longevity.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neurexin 1 (NRXN1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35941, KIAA0578, DKFZp313P2036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroligin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
PubMed 
chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
gephyrin clustering involved in postsynaptic density assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroligin clustering involved in postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
postsynaptic density protein 95 clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle cycle IEA
Inferred from Electronic Annotation
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by endocannabinoid IEA
Inferred from Electronic Annotation
more info
 
vocal learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neurexin-1
Names
neurexin I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011878.1 RefSeqGene

    Range
    5001..1119032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135659.2NP_001129131.1  neurexin-1 isoform alpha2 precursor

    See identical proteins and their annotated locations for NP_001129131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) results from the use of the 5'-most promoter, referred to as alpha. It represents the longest transcript that encodes the longest isoform (alpha2) of the representative RefSeq variants. This isoform contains EGF-like, several laminin G, and syndecan domains.
    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
    Consensus CDS
    CCDS46282.1
    UniProtKB/Swiss-Prot
    Q9ULB1
    Related
    ENSP00000385142.1, OTTHUMP00000200525, ENST00000404971.5, OTTHUMT00000323894
    Conserved Domains (6) summary
    smart00294
    Location:14921510
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:543692
    LamG; Laminin G domain
    cd00054
    Location:720753
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14721511
    Syndecan; Syndecan domain
    pfam02210
    Location:9731101
    Laminin_G_2; Laminin G domain
  2. NM_001320156.3NP_001307085.1  neurexin-1 isoform gamma1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma1) results from the use of an alternate promoter, referred to as gamma. It contains an alternate 5' terminal exon and lacks all the exons, except the last two 3' terminal exons, compared to variant alpha2. Hence, the encoded isoform (gamma1) is considerably shorter with a distinct N-terminus lacking the EGF-like and laminin G domains, and containing only the syndecan domain compared to isoform alpha2.
    Source sequence(s)
    AC078994
    Consensus CDS
    CCDS82444.1
    UniProtKB/TrEMBL
    H7BYC7
    Related
    ENSP00000367510.4, OTTHUMP00000201216, ENST00000378262.7, OTTHUMT00000325296
    Conserved Domains (2) summary
    smart00294
    Location:87105
    4.1m; putative band 4.1 homologues' binding motif
    pfam01034
    Location:67106
    Syndecan; Syndecan domain
  3. NM_001320157.3NP_001307086.1  neurexin-1 isoform gamma2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma2) results from the use of an alternate promoter, referred to as gamma. It contains an alternate 5' terminal exon and lacks all the exons, except the last two 3' terminal exons (the penultimate exon uses an alternate in-frame donor splice site), compared to variant alpha2. Hence, the encoded isoform (gamma2) is considerably shorter with a distinct N-terminus lacking the EGF-like and laminin G domains, and containing only the syndecan domain compared to isoform alpha2.
    Source sequence(s)
    AC078994
    Consensus CDS
    CCDS82445.1
    UniProtKB/TrEMBL
    H0Y568
    Related
    ENSP00000396738.2, OTTHUMP00000278397, ENST00000412315.5, OTTHUMT00000323984
    Conserved Domains (2) summary
    smart00294
    Location:84102
    4.1m; putative band 4.1 homologues' binding motif
    pfam01034
    Location:64103
    Syndecan; Syndecan domain
  4. NM_001330077.1NP_001317006.1  neurexin-1 isoform alpha3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
    Consensus CDS
    CCDS82449.1
    UniProtKB/TrEMBL
    A0A1D5RMU6
    Related
    ENSP00000486879.1, ENST00000630543.2
    Conserved Domains (6) summary
    smart00294
    Location:14441462
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:495644
    LamG; Laminin G domain
    cd00054
    Location:672705
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14241463
    Syndecan; Syndecan domain
    pfam02210
    Location:9251053
    Laminin_G_2; Laminin G domain
  5. NM_001330078.1NP_001317007.1  neurexin-1 isoform alpha4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
    Consensus CDS
    CCDS82451.1
    UniProtKB/TrEMBL
    E7ERL8
    Related
    ENSP00000385017.2, ENST00000401669.6
    Conserved Domains (6) summary
    smart00294
    Location:14521470
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:503652
    LamG; Laminin G domain
    cd00054
    Location:680713
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14321471
    Syndecan; Syndecan domain
    pfam02210
    Location:9331061
    Laminin_G_2; Laminin G domain
  6. NM_001330079.1NP_001317008.1  neurexin-1 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (6) is much shorter than isoform alpha2.
    Source sequence(s)
    AC007682
    Consensus CDS
    CCDS86838.1
    UniProtKB/TrEMBL
    A0A0D9SEQ7
    Related
    ENSP00000485912.1, ENST00000626899.1
    Conserved Domains (1) summary
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  7. NM_001330081.1NP_001317010.1  neurexin-1 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (7) is much shorter than isoform alpha2.
    Source sequence(s)
    AC007682
    Consensus CDS
    CCDS86840.1
    UniProtKB/TrEMBL
    E7EQN4
    Related
    ENSP00000385310.1, ENST00000405581.3
    Conserved Domains (1) summary
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  8. NM_001330082.1NP_001317011.1  neurexin-1 isoform alpha5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
    Consensus CDS
    CCDS82450.1
    UniProtKB/TrEMBL
    A0A0D9SEP4
    Related
    ENSP00000485887.1, ENST00000625672.2
    Conserved Domains (6) summary
    smart00294
    Location:14411459
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:495644
    LamG; Laminin G domain
    cd00054
    Location:672705
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14211460
    Syndecan; Syndecan domain
    pfam02210
    Location:9251053
    Laminin_G_2; Laminin G domain
  9. NM_001330083.1NP_001317012.1  neurexin-1 isoform alpha6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  10. NM_001330084.1NP_001317013.1  neurexin-1 isoform alpha7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  11. NM_001330085.1NP_001317014.1  neurexin-1 isoform alpha8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  12. NM_001330086.1NP_001317015.1  neurexin-1 isoform alpha9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  13. NM_001330087.1NP_001317016.1  neurexin-1 isoform alpha10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  14. NM_001330088.1NP_001317017.1  neurexin-1 isoform alpha11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  15. NM_001330089.1NP_001317018.1  neurexin-1 isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks multiple 3' coding exons and contains an alternate 3' exon structure compared to variant alpha2. The encoded isoform (8) is much shorter than isoform alpha2 and has a distinct C-terminus.
    Source sequence(s)
    AC007682, BX113737
  16. NM_001330090.1NP_001317019.1  neurexin-1 isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (9) is much shorter than isoform alpha2 and has a distinct C-terminus.
    Source sequence(s)
    AC007682
    Related
    ENSP00000490494.1, ENST00000637511.1
  17. NM_001330091.1NP_001317020.1  neurexin-1 isoform beta2

    Status: REVIEWED

    Source sequence(s)
    AC068725, AC069550, AC078994
    Consensus CDS
    CCDS82447.1
    UniProtKB/TrEMBL
    A0A0D9SEM5
    Related
    ENSP00000485815.1, ENST00000628364.2
  18. NM_001330092.1NP_001317021.1  neurexin-1 isoform beta3

    Status: REVIEWED

    Source sequence(s)
    AC068725, AC069550, AC078994
    Consensus CDS
    CCDS82446.1
    UniProtKB/Swiss-Prot
    P58400
    Related
    ENSP00000385580.2, ENST00000401710.5
    Conserved Domains (3) summary
    smart00294
    Location:417435
    4.1m; putative band 4.1 homologues' binding motif
    cd00110
    Location:90209
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:397436
    Syndecan; Syndecan domain
  19. NM_001330093.1NP_001317022.1  neurexin-1 isoform alpha12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  20. NM_001330094.1NP_001317023.1  neurexin-1 isoform alpha13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  21. NM_001330095.1NP_001317024.1  neurexin-1 isoform alpha14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  22. NM_001330096.1NP_001317025.1  neurexin-1 isoform alpha15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
  23. NM_001330097.1NP_001317026.1  neurexin-1 isoform beta4

    Status: REVIEWED

    Source sequence(s)
    AC068725, AC069550, AC078994
  24. NM_004801.5NP_004792.1  neurexin-1 isoform alpha1 precursor

    See identical proteins and their annotated locations for NP_004792.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) results from the use of the 5'-most promoter, referred to as alpha. It lacks two in-frame exons and uses an alternate in-frame donor splice site at an internal exon compared to variant alpha2. The resulting isoform (alpha1) is shorter missing a few internal protein segments compared to isoform alpha2. This isoform contains EGF-like, several laminin G, and syndecan domains.
    Source sequence(s)
    AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
    Consensus CDS
    CCDS54360.1
    UniProtKB/Swiss-Prot
    Q9ULB1
    Related
    ENSP00000384311.2, OTTHUMP00000201211, ENST00000406316.6, OTTHUMT00000325291
    Conserved Domains (6) summary
    smart00294
    Location:14221440
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:503652
    LamG; Laminin G domain
    cd00054
    Location:680713
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14021441
    Syndecan; Syndecan domain
    pfam02210
    Location:9331061
    Laminin_G_2; Laminin G domain
  25. NM_138735.4NP_620072.1  neurexin-1 isoform beta1

    See identical proteins and their annotated locations for NP_620072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta1) results from the use of an alternate promoter, referred to as beta. It contains an alternate 5' terminal exon and lacks most of the 5' exons and another exon in the 3' region compared to variant alpha2. The resulting isoform (beta1) is shorter with a distinct N-terminus lacking the EGF-like domain and containing fewer laminin G domains compared to isoform alpha2.
    Source sequence(s)
    AC068725, AC069550, AC078994
    Consensus CDS
    CCDS1845.1
    UniProtKB/Swiss-Prot
    P58400
    Related
    ENSP00000341184.5, OTTHUMP00000159578, ENST00000342183.9, OTTHUMT00000251372
    Conserved Domains (3) summary
    smart00294
    Location:387405
    4.1m; putative band 4.1 homologues' binding motif
    pfam01034
    Location:367406
    Syndecan; Syndecan domain
    pfam02210
    Location:121239
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    49918505..51032536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005327.2XP_016860816.1  neurexin-1 isoform X27

  2. XM_017005325.2XP_016860814.1  neurexin-1 isoform X25

  3. XM_006712137.4XP_006712200.1  neurexin-1 isoform X23

    Conserved Domains (6) summary
    smart00294
    Location:14261444
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14061445
    Syndecan; Syndecan domain
    pfam02210
    Location:9401068
    Laminin_G_2; Laminin G domain
  4. XM_017005322.2XP_016860811.1  neurexin-1 isoform X20

  5. XM_017005303.2XP_016860792.1  neurexin-1 isoform X1

  6. XM_017005314.2XP_016860803.1  neurexin-1 isoform X13

  7. XM_017005310.2XP_016860799.1  neurexin-1 isoform X9

  8. XM_011533178.3XP_011531480.1  neurexin-1 isoform X22

    Conserved Domains (6) summary
    smart00294
    Location:14291447
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:489638
    LamG; Laminin G domain
    cd00054
    Location:666699
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14091448
    Syndecan; Syndecan domain
    pfam02210
    Location:9101038
    Laminin_G_2; Laminin G domain
  9. XM_017005316.2XP_016860805.1  neurexin-1 isoform X14

  10. XM_017005326.2XP_016860815.1  neurexin-1 isoform X26

  11. XM_017005307.2XP_016860796.1  neurexin-1 isoform X5

  12. XM_017005304.2XP_016860793.1  neurexin-1 isoform X2

  13. XM_011533175.3XP_011531477.1  neurexin-1 isoform X17

    UniProtKB/TrEMBL
    A0A0R4J2G7
    Related
    ENSP00000434015.2, OTTHUMP00000228853, ENST00000405472.7
    Conserved Domains (6) summary
    smart00294
    Location:14401458
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:491640
    LamG; Laminin G domain
    cd00054
    Location:668701
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14201459
    Syndecan; Syndecan domain
    pfam02210
    Location:9211049
    Laminin_G_2; Laminin G domain
  14. XM_017005306.2XP_016860795.1  neurexin-1 isoform X4

  15. XM_017005318.2XP_016860807.1  neurexin-1 isoform X16

  16. XM_017005311.2XP_016860800.1  neurexin-1 isoform X11

  17. XM_017005320.2XP_016860809.1  neurexin-1 isoform X18

  18. XM_017005308.2XP_016860797.1  neurexin-1 isoform X6

  19. XM_017005324.2XP_016860813.1  neurexin-1 isoform X24

  20. XM_017005315.2XP_016860804.1  neurexin-1 isoform X15

  21. XM_011533172.3XP_011531474.1  neurexin-1 isoform X12

    Conserved Domains (6) summary
    smart00294
    Location:14501468
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14301469
    Syndecan; Syndecan domain
    pfam02210
    Location:9311059
    Laminin_G_2; Laminin G domain
  22. XM_017005309.2XP_016860798.1  neurexin-1 isoform X8

  23. XM_011533177.3XP_011531479.1  neurexin-1 isoform X21

    Conserved Domains (6) summary
    smart00294
    Location:14291447
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14091448
    Syndecan; Syndecan domain
    pfam02210
    Location:9401068
    Laminin_G_2; Laminin G domain
  24. XM_005264642.4XP_005264699.1  neurexin-1 isoform X10

    Conserved Domains (6) summary
    smart00294
    Location:14561474
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14361475
    Syndecan; Syndecan domain
    pfam02210
    Location:9401068
    Laminin_G_2; Laminin G domain
  25. XM_011533167.3XP_011531469.1  neurexin-1 isoform X7

    Conserved Domains (6) summary
    smart00294
    Location:14591477
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14391478
    Syndecan; Syndecan domain
    pfam02210
    Location:9401068
    Laminin_G_2; Laminin G domain
  26. XM_017005321.2XP_016860810.1  neurexin-1 isoform X19

  27. XM_017005305.2XP_016860794.1  neurexin-1 isoform X3

  28. XM_011533183.2XP_011531485.1  neurexin-1 isoform X31

    Conserved Domains (5) summary
    smart00294
    Location:11701188
    4.1m; putative band 4.1 homologues' binding motif
    smart00282
    Location:230379
    LamG; Laminin G domain
    cd00054
    Location:407440
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01034
    Location:11501189
    Syndecan; Syndecan domain
    pfam02210
    Location:651779
    Laminin_G_2; Laminin G domain
  29. XM_017005334.2XP_016860823.1  neurexin-1 isoform X32

  30. XM_017005329.2XP_016860818.1  neurexin-1 isoform X28

  31. XM_011533180.3XP_011531482.1  neurexin-1 isoform X29

    Conserved Domains (4) summary
    smart00282
    Location:510659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:9401068
    Laminin_G_2; Laminin G domain
  32. XM_006712140.4XP_006712203.2  neurexin-1 isoform X30

  33. XM_024453246.1XP_024309014.1  neurexin-1 isoform X35

    Conserved Domains (2) summary
    smart00282
    Location:307424
    LamG; Laminin G domain
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  34. XM_024453245.1XP_024309013.1  neurexin-1 isoform X34

    Conserved Domains (2) summary
    smart00282
    Location:307432
    LamG; Laminin G domain
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  35. XM_024453244.1XP_024309012.1  neurexin-1 isoform X33

    Conserved Domains (2) summary
    smart00282
    Location:307439
    LamG; Laminin G domain
    cd00110
    Location:30190
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
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