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Ube2n ubiquitin-conjugating enzyme E2N [ Mus musculus (house mouse) ]

Gene ID: 93765, updated on 9-May-2024

Summary

Official Symbol
Ube2nprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Nprovided by MGI
Primary source
MGI:MGI:1934835
See related
Ensembl:ENSMUSG00000074781 AllianceGenome:MGI:1934835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBC13; 1500026J17Rik
Summary
Enables ubiquitin conjugating enzyme activity. Involved in protein K63-linked ubiquitination. Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in brain. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 37.1), CNS E18 (RPKM 34.6) and 24 other tissues See more
Orthologs
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Genomic context

See Ube2n in Genome Data Viewer
Location:
10 C2; 10 49.41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95351024..95381520)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95515162..95545658)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene predicted gene, 46239 Neighboring gene STARR-seq mESC enhancer starr_27642 Neighboring gene STARR-positive B cell enhancer ABC_E8362 Neighboring gene nudix hydrolase 4 Neighboring gene STARR-seq mESC enhancer starr_27645 Neighboring gene microRNA 3058 Neighboring gene predicted gene, 33336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in postreplication repair ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of UBC13-MMS2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of UBC13-UEV1A complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of ubiquitin conjugating enzyme complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 N
Names
E2 ubiquitin-conjugating enzyme N
bendless-like ubiquitin-conjugating enzyme
ubiquitin carrier protein N
ubiquitin-protein ligase N
NP_542127.1
XP_006514407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080560.3NP_542127.1  ubiquitin-conjugating enzyme E2 N

    See identical proteins and their annotated locations for NP_542127.1

    Status: VALIDATED

    Source sequence(s)
    AC159135
    Consensus CDS
    CCDS48677.1
    UniProtKB/Swiss-Prot
    P61089, Q3TSL6, Q6ZWZ0, Q9DAJ6
    UniProtKB/TrEMBL
    A2RTT4
    Related
    ENSMUSP00000096932.4, ENSMUST00000099329.5
    Conserved Domains (1) summary
    cl00154
    Location:4151
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95351024..95381520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514344.5XP_006514407.1  ubiquitin-conjugating enzyme E2 N isoform X1

    Conserved Domains (1) summary
    cl00154
    Location:29170
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...