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Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 93747, updated on 5-Feb-2023

Summary

Official Symbol
Echs1provided by MGI
Official Full Name
enoyl Coenzyme A hydratase, short chain, 1, mitochondrialprovided by MGI
Primary source
MGI:MGI:2136460
See related
Ensembl:ENSMUSG00000025465 AllianceGenome:MGI:2136460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCEH; mECH; mECH1
Summary
Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 119.4), kidney adult (RPKM 88.5) and 28 other tissues See more
Orthologs
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Genomic context

See Echs1 in Genome Data Viewer
Location:
7; 7 F4
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139685623..139696334, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140105710..140116421, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline-rich acidic protein 1 Neighboring gene fucose mutarotase Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily AE member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enoyl-CoA hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
enoyl-CoA hydratase, mitochondrial
Names
enoyl-CoA hydratase 1
short-chain enoyl-CoA hydratase
NP_444349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053119.3NP_444349.1  enoyl-CoA hydratase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_444349.1

    Status: VALIDATED

    Source sequence(s)
    AK040391, BC072658
    Consensus CDS
    CCDS21964.1
    UniProtKB/Swiss-Prot
    Q8BH95, Q99LX7
    Related
    ENSMUSP00000026538.7, ENSMUST00000026538.13
    Conserved Domains (2) summary
    PRK05617
    Location:36288
    PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
    cl23717
    Location:32288
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139685623..139696334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)