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ezrA negative regulator of FtsZ ring formation [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937337, updated on 12-Feb-2021

Summary

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Gene symbol
ezrA
Gene description
negative regulator of FtsZ ring formation
Locus tag
BSU_29610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU29610
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Genomic context

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Sequence:
NC_000964.3 (3029729..3031417, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase Neighboring gene branched-chain amino acid-Na+ symporter Neighboring gene histidinol phosphate phosphatase Neighboring gene regulator of FtsZ defining the chromosome region captured in the forespore Neighboring gene free methionine-(R)-sulfoxide reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Cleverley RM, et al. Nat Commun, 2014 Nov 18. PMID 25403286, Free PMC Article
  2. Functional domain analysis of the cell division inhibitor EzrA. Land AD, et al. PLoS One, 2014. PMID 25068683, Free PMC Article
  3. A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ. Singh JK, et al. Biochemistry, 2007 Sep 25. PMID 17718511
  4. Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis. Claessen D, et al. Mol Microbiol, 2008 May. PMID 18363795
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The EzrA structure is bent into a semicircle, providing the protein with the potential to interact at both N- and C-termini with adjacent membrane-bound divisome components.
    Title: Structure and function of a spectrin-like regulator of bacterial cytokinesis.
  2. chimeric analysis indicates that EzrA's transmembrane anchor plays a generic role: concentrating EzrA at the plasma membrane where presumably it can most effectively modulate FtsZ assembly
    Title: Functional domain analysis of the cell division inhibitor EzrA.
  3. EzrA mainly promotes the recruitment of PBP1 to division sites.
    Title: Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
  4. The data together showed that EzrA binds to the C-terminal tail of FtsZ. FtsA, a positive regulator of FtsZ assembly, is also known to interact with the C-terminal tail of FtsZ.
    Title: A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
negative regulator of FtsZ ring formation
NP_390839.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3029729..3031417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390839.1 negative regulator of FtsZ ring formation [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390839.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG4477
    Location:1 → 562
    EzrA; Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O34894.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases