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menE O-succinylbenzoic acid-CoA ligase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937132, updated on 6-Jun-2024

Summary

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Gene symbol
menE
Gene description
O-succinylbenzoic acid-CoA ligase
Locus tag
BSU_30790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU30790
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Genomic context

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Sequence:
NC_000964.3 (3147350..3148810, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene manganese ABC transporter (ATP-binding protein) Neighboring gene manganese ABC transporter (manganese binding lipoprotein) Neighboring gene O-succinylbenzoate-CoA synthase Neighboring gene dihydroxynapthoic acid synthetase Neighboring gene 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode. Chen Y, et al. J Biol Chem, 2017 Jul 21. PMID 28559280, Free PMC Article
  2. Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate. Chen Y, et al. Biochemistry, 2016 Dec 6. PMID 27933791
  3. Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase. Chen Y, et al. J Biol Chem, 2015 Sep 25. PMID 26276389, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that o-succinylbenzoyl-CoA synthetase exhibits a thioesterification active site specifically conserved among orthologues and a substrate-binding mode distinct from those of many other acyl/aryl-CoA synthetases.
    Title: Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode.
  2. Findings suggest better understand the domain alternation catalytic mechanism of MenE (o-succinylbenzoyl-CoA (OSB-CoA) synthetase) as well as many other adenylating enzymes.
    Title: Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate.
  3. Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase.
    Title: Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
O-succinylbenzoic acid-CoA ligase
NP_390957.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3147350..3148810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_390957.1 O-succinylbenzoic acid-CoA ligase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_390957.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1KXN6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23971.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases