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KIF3B kinesin family member 3B [ Homo sapiens (human) ]

Gene ID: 9371, updated on 6-May-2021

Summary

Official Symbol
KIF3Bprovided by HGNC
Official Full Name
kinesin family member 3Bprovided by HGNC
Primary source
HGNC:HGNC:6320
See related
Ensembl:ENSG00000101350 MIM:603754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLA8; RP89; HH0048; KLP-11
Summary
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.2), kidney (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

See KIF3B in Genome Data Viewer
Location:
20q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32277651..32335011)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30865454..30922814)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PLAG1 like zinc finger 2 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene microRNA 1825 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene nucleolar protein 4 like Neighboring gene uncharacterized LOC101929698

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0359

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent microtubule motor activity, plus-end-directed TAS
Traceable Author Statement
more info
PubMed 
enables ATPase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables intraciliary transport particle B binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport TAS
Traceable Author Statement
more info
PubMed 
involved_in anterograde dendritic transport of neurotransmitter receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of left/right symmetry TAS
Traceable Author Statement
more info
PubMed 
involved_in intraciliary transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
 
involved_in mitotic centrosome separation TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
PubMed 
involved_in opsin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plus-end-directed vesicle transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in ciliary tip TAS
Traceable Author Statement
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
part_of plus-end kinesin complex TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with spindle microtubule NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF3B
Names
microtubule plus end-directed kinesin motor 3B
NP_004789.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004798.4NP_004789.1  kinesin-like protein KIF3B

    See identical proteins and their annotated locations for NP_004789.1

    Status: REVIEWED

    Source sequence(s)
    AB002357, AL121897, AL353976, AL354800, BC136311, DA805755
    Consensus CDS
    CCDS13200.1
    UniProtKB/Swiss-Prot
    O15066
    Related
    ENSP00000364864.3, ENST00000375712.4
    Conserved Domains (2) summary
    COG1196
    Location:352614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32277651..32335011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001754435.2 RNA Sequence

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