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rocG glutamate dehydrogenase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 937066, updated on 6-Oct-2023
Gene symbol
rocG
Gene description
glutamate dehydrogenase
Locus tag
BSU_37790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU37790
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Sequence:
NC_000964.3 (3880740..3882014, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene basic aminoacid permease Neighboring gene putative N-deacylase involved in arginine and ornithine utilization Neighboring gene delta-1-pyrroline-5 carboxylate dehydrogenase Neighboring gene biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity Neighboring gene putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat) Neighboring gene putative dTDP-4-dehydrorhamnose reductase

Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilis. Khan MI, et al. Biosci Biotechnol Biochem, 2005 Oct. PMID 16244435
  2. Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. Bertram R, et al. FEMS Microbiol Lett, 2006 Jun. PMID 16684115
  3. Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis. Lee YH, et al. J Bacteriol, 2012 Mar. PMID 22178969, Free PMC Article
  4. A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC. Commichau FM, et al. Mol Microbiol, 2007 Aug. PMID 17608797
  5. Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis. Tanaka K, et al. BMC Microbiol, 2015 Feb 22. PMID 25880922, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
    Title: Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.
  2. The authors conclude that RocG glutamate dehydrogenase activity affects the expression of the sigma(W) regulon, by pathways that are yet unclear.
    Title: Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis.
  3. The genetic and biochemical data presented here show that the glutamate dehydrogenase RocG is able to bind to and concomitantly inactivate the activator protein GltC.
    Title: A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC.
  4. Glutamate dehydrogenase cloned from the rocG gene was characterized for thermostability, oligomerization, and substrate specificity. Random mutagenesis produced an enzyme with missense mutation that enhanced thermostability and k(cat).
    Title: Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilis.
  5. Regulated expression of HPrK/P does not affect carbon catabolite repression of rocG
    Title: Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis.
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Homology

Preferred Names
glutamate dehydrogenase
NP_391659.2
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    3880740..3882014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391659.2 glutamate dehydrogenase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391659.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1IB73
    Conserved Domains (1) summary
    COG0334
    Location:15 → 424
    GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39633.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases